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http://dx.doi.org/10.4196/kjpp.2013.17.4.359

Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse  

Hong, Seung Hwa (Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine)
Sung, Rohyun (Department of Pathology, Chungbuk National University College of Medicine)
Kim, Young Chul (Department of Physiology, Chungbuk National University College of Medicine)
Suzuki, Hikaru (Department of Physiology, Nagoya City University Medical School)
Choi, Woong (Department of Pharmacology, Chungbuk National University College of Medicine)
Park, Yeon Jin (Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine)
Ji, Ill Woon (Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine)
Kim, Chan Hyung (Department of Pharmacology, Chungbuk National University College of Medicine)
Myung, Sun Chul (Department of Urology, College of Medicine, Chung-Ang University)
Lee, Moo Yeol (Department of Physiology, College of Medicine, Chung-Ang University)
Kang, Tong Mook (Department of Physiology, Sungkyunkwan University School of Medicine)
You, Ra Young (Department of Physiology, Chungbuk National University College of Medicine)
Lee, Kwang Ju (Department of Pathology, Chungbuk National University College of Medicine)
Lim, Seung Woon (Department of Anesthesiology and Pain Medicine, Chungbuk National University College of Medicine)
Yun, Hyo-Yung (Department of Surgery, Chungbuk National University College of Medicine)
Song, Young-Jin (Department of Surgery, Chungbuk National University College of Medicine)
Xu, Wen-Xie (Department of Physiology, Shanghai Jiaotong University School of Medicine)
Kim, Hak Soon (Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine)
Lee, Sang Jin (Department of Physiology, Chungbuk National University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.17, no.4, 2013 , pp. 359-365 More about this Journal
Abstract
Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of $K^+$ channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, $K^+$ conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretch-activated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.
Keywords
Relaxation; TASK-2; Uterus;
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Times Cited By KSCI : 2  (Citation Analysis)
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