Effects of Protopanaxatriol-Ginsenoside Metabolites on Rat ![]() |
Shin, Tae-Joon
(Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Hwang, Sung-Hee (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Choi, Sun-Hye (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Lee, Byung-Hwan (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Kang, Ji-Yeon (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Kim, Hyeon-Joong (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Zukin, R. Suzanne (Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine) Rhim, Hye-Whon (Life Science Division, KIST) Nah, Seung-Yeol (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) |
1 | Chapman AG. Glutamate and epilepsy. J Nutr. 2000;130(4S Suppl):1043S-1045S. DOI |
2 | Ikonomidou C, Turski L. Neurodegenerative disorders: clues from glutamate and energy metabolism. Crit Rev Neurobiol. 1996;10:239-263. DOI ScienceOn |
3 | Lee HG, Zhu X, Ghanbari HA, Ogawa O, Raina AK, O'Neill MJ, Perry G, Smith MA. Differential regulation of glutamate receptors in Alzheimer's disease. Neurosignals. 2002;11:282-292. DOI ScienceOn |
4 | Qian T, Cai Z, Wong RN, Mak NK, Jiang ZH. In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;816:223-232. DOI ScienceOn |
5 |
Zhao Q, Zheng X, Jiang J, Zhou H, Hu P. Determination of ginsenoside |
6 |
Lee JH, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Lee SM, Park YS, Lee JH, Kim SS, Kim HC, Lee BY, Nah SY. Effects of ginsenosides and their metabolites on voltagedependent |
7 |
Choi SH, Lee JH, Pyo MK, Lee BH, Shin TJ, Hwang SH, Kim BR, Lee SM, Oh JW, Kim HC, Bae CS, Rhim H, Nah SY. Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type |
8 |
Lee JH, Jeong SM, Kim JH, Lee BH, Yoon IS, Lee JH, Choi SH, Kim DH, Rhim H, Kim SS, Kim JI, Jang CG, Song JH, Nah SY. Characteristics of ginsenoside |
9 |
Lee JH, Lee BH, Choi SH, Yoon IS, Shin TJ, Pyo MK, Lee SM, Kim HC, Nah SY. Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated |
10 | Hasegawa H, Suzuki R, Nagaoka T, Tezuka Y, Kadota S, Saiki I. Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acidconjugate of protopanaxatriol. Biol Pharm Bull. 2002;25:861-866. DOI ScienceOn |
11 | Wakabayashi C, Murakami K, Hasegawa H, Murata J, Saiki I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun. 1998;246:725-730. DOI ScienceOn |
12 | Lee BH, Jeong SM, Lee JH, Kim JH, Yoon IS, Lee JH, Choi SH, Lee SM, Chang CG, Kim HC, Han Y, Paik HD, Kim Y, Nah SY. Quercetin inhibits the 5-hydroxytryptamine type 3 receptor-mediated ion current by interacting with pre-transmembrane domain I. Mol Cells. 2005;20:69-73. |
13 |
Zheng X, Zhang L, Wang AP, Bennett MV, Zukin RS. |
14 | Durand GM, Bennett MV, Zukin RS. Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci USA. 1993;90:6731-6735. DOI ScienceOn |
15 | Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992;256:1217-1221. DOI ScienceOn |
16 |
Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Oh JW, Bae CH, Lee SH, Nah SY. Differential effects of ginsenoside metabolites on HERG |
17 | Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci. 1994;17:31-108. DOI ScienceOn |
18 | Lee BH, Jeong SM, Lee JH, Kim DH, Kim JH, Kim JI, Shin HC, Lee SM, Nah SY. Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells. 2004;17:51-56. |
19 | Lee JH, Jeong SM, Lee BH, Kim DH, Kim JH, Kim JI, Lee SM, Nah SY. Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes. Arch Pharm Res. 2003;26:868-873. DOI ScienceOn |
20 | Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature. 1991;354:31-37. DOI ScienceOn |
21 | Carroll RC, Zukin RS. NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci. 2002;25:571-577. DOI ScienceOn |
22 | Choi DW. Excitotoxic cell death. J Neurobiol. 1992;23:1261-1276. DOI |
23 | Soundarapandian MM, Tu WH, Peng PL, Zervos AS, Lu Y. AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke. Mol Neurobiol. 2005;32:145-155. DOI ScienceOn |
24 | Nah SY. Ginseng: recent advances and trends. Korean J Ginseng Sci. 1997;21:1-12. |
25 | Nah SY, Kim DH, Rhim H. Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev. 2007;13:381-404. |
26 | Kim S, Ahn K, Oh TH, Nah SY, Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun. 2002;296:247-254. DOI ScienceOn |
27 |
Kim S, Kim T, Ahn K, Park WK, Nah SY, Rhim H. Ginsenoside |
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