3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-![]() |
Lee, Jae-Won
(Department of Pharmacology, College of Medicine, Kangwon National University)
Bae, Chang-Jun (Department of Laboratory Animal Resources, National Institute of Food and Drug Evaluation, Korea FDA) Choi, Yong-Jun (Department of Pharmacology, College of Medicine, Kangwon National University) Kim, Song-In (Department of Pharmacology, College of Medicine, Kangwon National University) Kim, Nam-Ho (Department of Pharmacology, College of Medicine, Kangwon National University) Lee, Hee-Jae (Department of Pharmacology, College of Medicine, Kangwon National University) Kim, Sung-Soo (Department of Pharmacology, College of Medicine, Kangwon National University) Kwon, Yong-Soo (College of Pharmacy, Kangwon National University) Chun, Wan-Joo (Department of Pharmacology, College of Medicine, Kangwon National University) |
1 | Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors. 2001;15:87-89. DOI |
2 | Moon DO, Park SY, Lee KJ, Heo MS, Kim KC, Kim MO, Lee JD, Choi YH, Kim GY. Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol. 2007;7:1092-1101. DOI ScienceOn |
3 | Zheng LT, Ock J, Kwon BM, Suk K. Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Int Immunopharmacol. 2008;8:484-494. DOI ScienceOn |
4 | Chao CC, Hu S, Close K, Choi CS, Molitor TW, Novick WJ, Peterson PK. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis. 1992;166:847-853. DOI ScienceOn |
5 | Lee IS, Lim J, Gal J, Kang JC, Kim HJ, Kang BY, Choi HJ. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int. 2011;58:153-160. DOI ScienceOn |
6 | Steinbrecher T, Hrenn A, Dormann KL, Merfort I, Labahn A. Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations. Bioorg Med Chem. 2008;16:2385-2390. DOI ScienceOn |
7 | Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H, Ushio H. Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem Biophys Res Commun. 2007;358:615-619. DOI ScienceOn |
8 | Kim YC. Neuroprotective phenolics in medicinal plants. Arch Pharm Res. 2010;33:1611-1632. DOI ScienceOn |
9 | Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725-734. DOI ScienceOn |
10 | Lee JW, Cheong IY, Kim HS, Lee JJ, Lee YS, Kwon YS, Kim MJ, Lee HJ, Kim SS, Chun W. Anti-inflammatory activity of 1-docosanoyl cafferate isolated from rhus verniciflua in LPS-stimulated BV2 microglial cells. Korean J Physiol Pharmacol. 2011;15:9-15. DOI ScienceOn |
11 | Lee Y, Shin DH, Kim JH, Hong S, Choi D, Kim YJ, Kwak MK, Jung Y. Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. Eur J Pharmacol. 2010;643:21-28. DOI ScienceOn |
12 | Rabe C, Steenkamp JA, Joubert E, Burger JF, Ferreira D. Phenolic metabolites from rooibos tea (Aspalathus linearis). Phytochem. 1994;35:1559-1565. DOI ScienceOn |
13 | Ock J, Kim S, Suk K. Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol Res. 2009;59:414-422. DOI ScienceOn |
14 | Zheng LT, Ryu GM, Kwon BM, Lee WH, Suk K. Antiinflammatory effects of catechols in lipopolysaccharide- stimulated microglia cells: inhibition of microglial neurotoxicity. Eur J Pharmacol. 2008;588:106-113. DOI ScienceOn |
15 | Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318. DOI ScienceOn |
16 | Graeber MB, Streit WJ. Microglia: biology and pathology. Acta Neuropathol. 2010;119:89-105. DOI ScienceOn |
17 | Aquilano K, Baldelli S, Rotilio G, Ciriolo MR. Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res. 2008;33:2416-2426. DOI ScienceOn |
18 | Ray B, Lahiri DK. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009;9:434-444. DOI ScienceOn |
19 | Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 1994;10:405-455. DOI ScienceOn |
20 | Kuprash DV, Udalova IA, Turetskaya RL, Rice NR, Nedospasov SA. Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene. 1995;11:97-106. |
21 | Sugama S. Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders. Med Hypotheses. 2009;73:1031-1034. DOI ScienceOn |
22 | Perry VH, Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 1988;11:273-277. DOI ScienceOn |
23 | Hailer NP. Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog Neurobiol. 2008;84:211-233. DOI ScienceOn |
24 | Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989;24:173-182. DOI ScienceOn |
25 | Matsumoto H. Some markers reflecting the pathology and disease activity of multiple sclerosis. No To Shinkei. 1992;44:95-102. |
26 | McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis Assoc Disord. 1998;12 Suppl 2:S1-6. DOI |
27 | Tuttolomondo A, Di Raimondo D, di Sciacca R, Pinto A, Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14:3574-3589. DOI ScienceOn |
28 | Merrill JE, Benveniste EN. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 1996;19:331-338. DOI ScienceOn |
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