Browse > Article

The Inhibitory Effect of Quercetin-3-O-${\beta}$-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats  

Min, Young-Sil (College of Pharmacy, Chung-Ang University)
Lee, Se-Eun (College of Pharmacy, Chung-Ang University)
Hong, Seung-Tae (College of Pharmacy, Chung-Ang University)
Kim, Hyun-Sik (College of Pharmacy, Chung-Ang University)
Choi, Byung-Chul (College of Pharmacy, Chung-Ang University)
Sim, Sang-Soo (College of Pharmacy, Chung-Ang University)
Whang, Wan-Kyun (College of Pharmacy, Chung-Ang University)
Sohn, Uy-Dong (College of Pharmacy, Chung-Ang University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.13, no.4, 2009 , pp. 295-300 More about this Journal
Abstract
It was evaluated the inhibitory action of quercetin-3-O-${\beta}$-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
Keywords
Reflux esophagitis; Lipid peroxidation; Gastritis; Quercetin-3-O-${\beta}$-D-glucuronopyranoside;
Citations & Related Records

Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
연도 인용수 순위
1 Bell NJ, Burget D, Howden CW, Wilkinson J, Hunt RH. Appropriate acid suppression for the management of gastro-oesophageal reflux disease. Digestion 51 Suppl 1: 59−67, 1992   DOI   ScienceOn
2 Bradford MM. A rapid, sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248−254, 1976   DOI   PUBMED   ScienceOn
3 Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, Perry CA. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 147: 278−292, 1995   ScienceOn
4 Gordon MH, Roedig-Penman A. Antioxidant activity of quercetin and myricetin in liposomes. Chem Phys Lipids 97: 79−85, 1998   DOI   PUBMED   ScienceOn
5 Haegele AD, Briggs SP, Thompson HJ. Antioxidant status and dietary lipid unsaturation modulate oxidative DNA damage. Free Radic Biol Med 16: 111−115, 1994   DOI   PUBMED   ScienceOn
6 Hollman PC, van Trijp JM, Buysman MN, van der Gaag MS, Mengelers MJ, de Vries JH, Katan MB. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 418: 152−156, 1997   DOI   PUBMED   ScienceOn
7 Lewis DA. Anti-inflammatory drugs from plant, marine sources. Agents Actions Suppl 27: 3−373, 1989   DOI   ScienceOn
8 Min YS, Yim SH, Bai KL, Choi HJ, Jeong JH, Song HJ, Park SY, Ham I, Whang WK, Sohn UD. The effects of apigenin-7-O- beta-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats. Auton Autacoid Pharmacol 25: 85−91, 2005   DOI   ScienceOn
9 Parmar NS, Hennings G. The gastric antisecretory activity of 3-methoxy-5,7,3'4'-tetrahydroxyflavan (ME)--a specific histidine decarboxylase inhibitor in rats. Agents Actions 15: 143−145, 1984   DOI   PUBMED   ScienceOn
10 Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933−956, 1996   DOI   PUBMED   ScienceOn
11 Biancani P, Sohn UD, Rich HG, Harnett KM, Behar J. Signal transduction pathways in esophageal and lower esophageal sphincter circular muscle. Am J Med 103: 23S−28S, 1997   DOI   ScienceOn
12 Jung SY, Choi S, Ko YS, Park CS, Oh S, Koh SR, Oh U, Oh JW, Rhee MH, Nah SY. Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. Mol Cells 12: 342−346, 2001   PUBMED   ScienceOn
13 Sohn UD, Cho JH, Song HJ, Sun YH, Hwang WK. M1903 Protective Effects of Quercetin-3-O-[beta]-D-Glucuronopyranoside (QGC) On Ethanol-Induced Cell Damage Involve Inhibitions of ROS Generation and Downstream Activation of the ERK in Feline Esophageal Epithelial Cells. Gastroenterology 136: A442, 2009   DOI   ScienceOn
14 Geetha T, Malhotra V, Chopra K, Kaur IP. Antimutagenic and antioxidant/prooxidant activity of quercetin. Indian J Exp Biol 43: 61−67, 2005   PUBMED   ScienceOn
15 Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30: 433−446, 2001   DOI   PUBMED   ScienceOn
16 Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 32: 1395−1401, 1987   DOI   PUBMED   ScienceOn
17 Stein HJ, Hinder RA, Oosthuizen MM. Gastric mucosal injury caused by hemorrhagic shock and reperfusion: protective role of the antioxidant glutathione. Surgery 108: 467−473, 1990   PUBMED   ScienceOn
18 Lee SE, Jang HS, Song HJ, Hwang WK, Sohn UD. M1904 Downstream Signal Transduction Induced By Interleukin-1 Beta-Stimulated ROS Generation and Anti-Oxidative Effects of Quercetin-3-O-[beta]-D-Glucuronopyranoside (QGC) in Feline Esophageal Epithelial Cells. Gastroenterology 136: A442−443, 2009   DOI   ScienceOn
19 Okabe S, Takinami Y, Iwata K, Yanagawa T. Mucosal protective effect of leminoprazole on reflux esophagitis induced in rats. Jpn J Pharmacol 69: 317−323, 1995   DOI
20 Alvarez A, Pomar F, Sevilla, Montero MJ. Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip. J Ethnopharmacol 67: 333−340, 1999   DOI   PUBMED   ScienceOn
21 Wetscher GJ, Perdikis G, Kretchmar DH, Stinson RG, Bagchi D, Redmond EJ, Adrian TE, Hinder RA. Esophagitis in Sprague-Dawley rats is mediated by free radicals. Dig Dis Sci 40: 1297−1305, 1995   DOI   PUBMED   ScienceOn
22 Nakamura K, Ozawa Y, Furuta Y, Miyazaki H. Effects of sodium polyacrylate (PANa) on acute esophagitis by gastric juice in rats. Jpn J Pharmacol 32: 445−456, 1982   DOI
23 Naya MJ, Pereboom D, Ortego J, Alda JO, Lanas A. Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. Gut 40: 175−181, 1997   DOI   PUBMED   ScienceOn
24 Bell NJ, Hunt RH. Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease. Gut 33: 118−124, 1992   DOI   PUBMED   ScienceOn
25 Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 52: 302−310, 1978   DOI   PUBMED
26 Gambhir SS, Goel RK, Das Gupta G. Anti-inflammatory & anti-ulcerogenic activity of amentoflavone. Indian J Med Res 85: 689−693, 1987
27 Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36: 838−849, 2004   DOI   PUBMED   ScienceOn
28 Hollman PC, Katan MB. Bioavailability and health effects of dietary flavonols in man. Arch Toxicol Suppl 20: 237−248, 1998   ScienceOn
29 Kvietys PR, Twohig B, Danzell J, Specian RD. Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology 98: 909−920, 1990   DOI   PUBMED   ScienceOn