Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells
![]() ![]() |
Kim, Mi-Hyoung
(Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
Byon, Yun-Young (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University) Ko, Eun-Ju (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University) Song, Jie-Young (Luboratory of Radiation Immunology, Korea Institute of Radiological and Medical Sciences) Yun, Yeon-Sook (Luboratory of Radiation Immunology, Korea Institute of Radiological and Medical Sciences) Shin, Taek-Yun (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine) Joo, Hong-Gu (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine) |
1 | Ahn JY, Choi IS, Shim JY, Yun EK, Yun YS, Jeong G, Song JY. The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur J Immunol 36: 37−45, 2006 DOI ScienceOn |
2 | Joo HG. Altered maturation of dendritic cells by taxol, an anticancer drug. J Vet Sci 4: 229−234, 2003 PUBMED ScienceOn |
3 | Song JY, Han SK, Bae KG, Lim DS, Son SJ, Jung IS, Yi SY, Yun YS. Radioprotective effects of ginsan, an immunomodulator. Radiat Res 159: 768−774, 2003 DOI ScienceOn |
4 | Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, Enk A, Steinman RM, Romani N, Schuler G. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 26: 659−668, 1996 DOI ScienceOn |
5 | Lu L, Bonham CA, Chambers FG, Watkins SC, Hoffman RA, Simmons RL, Thomson AW. Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis. J Immunol 157: 3577−3586, 1996 ScienceOn |
6 | Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res 17: 323−331, 1997 PUBMED |
7 | Steinman RM, Pack M, Inaba K. Dendritic cells in the T-cell areas of lymphoid organs. Immunol Rev 156: 25−37, 1997 DOI ScienceOn |
8 | Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol 152: 5208−5219, 1994 ScienceOn |
9 | Kim HJ, Kim MH, Byon YY, Park JW, Jee Y, Joo HG. Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells. J Vet Sci 8: 39−44, 2007 DOI ScienceOn |
10 | Song JY, Han SK, Son EH, Pyo SN, Yun YS, Yi SY. Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int Immunopharmacol 2: 857−865, 2002 DOI ScienceOn |
11 | Shin JY, Song JY, Yun YS, Yang HO, Rhee DK, Pyo S. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol Immunotoxicol 24: 469−482, 2002 DOI ScienceOn |
12 | Esche C, Shurin GV, Kirkwood JM, Wang GQ, Rabinowich H, Pirtskhalaishvili G, Shurin MR. Tumor necrosis factor-alpha- promoted expression of Bcl-2 and inhibition of mitochondrial cytochrome c release mediate resistance of mature dendritic cells to melanoma-induced apoptosis. Clin Cancer Res 7: 974s−979s, 2001 ScienceOn |
13 | Bonham CA, Lu L, Li Y, Hoffman RA, Simmons RL, Thomson AW. Nitric oxide production by mouse bone marrow-derived dendritic cells: implications for the regulation of allogeneic T cell responses. Transplantation 62: 1871−1877, 1996 DOI ScienceOn |
14 | Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 166: 4312−4318, 2001 |
15 | Joo HG, Goedegebuure PS, Sadanaga N, Nagoshi M, von Bernstorff W, Eberlein TJ. Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes. J Leukoc Biol 69: 555−564, 2001 ScienceOn |
16 | Mosca PJ, Hobeika AC, Clay TM, Nair SK, Thomas EK, Morse MA, Lyerly HK. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood 96: 3499−3504, 2000 ScienceOn |
17 | Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 106: 255−258, 2001 DOI ScienceOn |
18 | Kim MH, Joo HG. Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells. Immunol Lett 115: 138−143, 2008 DOI ScienceOn |
19 | Yoneyama H, Matsuno K, Matsushima K. Migration of dendritic cells. Int J Hematol 81: 204−207, 2005 DOI ScienceOn |
![]() |