Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo
![]() ![]() |
Lee, Hyun-Kyoung
(Departments of physiology and College of Medicine, Dong-A University)
Jung, Jun-Yang (Departments of physiology and College of Medicine, Dong-A University) Lee, Sang-Hwa (Microbiology, Medical Science Research Institute, College of Medicine, Dong-A University) Seo, Su-Yeong (Microbiology, Medical Science Research Institute, College of Medicine, Dong-A University) Suh, Duk-Joon (Departments of physiology and College of Medicine, Dong-A University) Park, Hwan-Tae (Departments of physiology and College of Medicine, Dong-A University) |
1 | Lee HK, Seo IA, Park HK, Park YM, Ahn KJ, Yoo YH, Park HT. Nidogen is a prosurvival and promigratory factor for adult Schwann cells. J Neurochem 102: 686−698, 2007 DOI ScienceOn |
2 | Lee HK, Seo IA, Suh DK, Hong JI, Yoo YH, Park HT. Interleukin-6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration. J Neurochem 108: 776−786, 2009 DOI ScienceOn |
3 | Monje PV, Bartlett Bunge M, Wood PM. Cyclic AMP synergistically enhances neuregulin-dependent ERK and Akt activation and cell cycle progression in Schwann cells. Glia 53: 649−659, 2006 DOI ScienceOn |
4 | Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol 172: 245−257, 2006a DOI ScienceOn |
5 | Ng YP, Cheung ZH, Ip NY. STAT3 as a downstream mediator of Trk signaling and functions. J Biol Chem 281: 15636−15644, 2006b DOI ScienceOn |
6 | Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241−250, 1995 DOI PUBMED ScienceOn |
7 | Cafferty WB, Gardiner NJ, Gavazzi I, Powell J, McMahon SB, Heath JK, Munson J, Cohen J, Thompson SW. Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci 21: 7161−7170, 2001 |
8 | Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17: 6508− 6516, 1997 PUBMED ScienceOn |
9 | Gartsbein M, Alt A, Hashimoto K, Nakajima K, Kuroki T, Tennenbaum T. The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation. J Cell Sci 119: 470−481, 2006 DOI ScienceOn |
10 | Hai M, Muja N, DeVries GH, Quarles RH, Patel PI. Comparative analysis of Schwann cell lines as model systems for myelin gene transcription studies. J Neurosci Res 69: 497−508, 2002 DOI ScienceOn |
11 | Jessen KR, Mirsky R. The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci 6: 671−682, 2005 DOI ScienceOn |
12 | Jirsova K, Sodaar P, Mandys V, Bar PR. Cold jet: a method to obtain pure Schwann cell cultures without the need for cytotoxic, apoptosis-inducing drug treatment. J Neurosci Methods 78: 133−137, 1997 DOI PUBMED ScienceOn |
13 | Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149: 1−38, 2003 |
14 | Sheu JY, Kulhanek DJ, Eckenstein FP. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 166: 392−402, 2000 DOI ScienceOn |
15 | Jain N, Zhang T, Fong SL, Lim CP, Cao X. Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). Oncogene 17: 3157−3167, 1998 DOI ScienceOn |
16 | Reich NC, Liu L. Tracking STAT nuclear traffic. Nat Rev Immunol 6: 602−612, 2006 DOI ScienceOn |
17 | Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, Lloyd AC. The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 23: 3061−3071, 2004 DOI ScienceOn |
18 | Jessen KR, Mirsky R. Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 56: 1552−1565, 2008 DOI ScienceOn |
19 | Bleuel A, Monard D. Regulation of protease nexin-1 and angiotensin II receptor subtype 1 expression: inverse relationship in experimental models of nerve injury. J Neurosci Res 42: 562−570, 1995 DOI ScienceOn |
20 | Shi X, Zhang H, Paddon H, Lee G, Cao X, Pelech S. Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest. Biochemistry 45: 5857−5867, 2006 DOI ScienceOn |
21 | Qiu J, Cafferty WB, McMahon SB, Thompson SW. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J Neurosci 25: 1645−1653, 2005 DOI ScienceOn |
22 | Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ. Ras/ERK1/2- mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation. J Biol Chem 282: 6415−6424, 2007 DOI ScienceOn |
23 | Battle TE, Frank DA. The role of STATs in apoptosis. Curr Mo Med 2: 381−392, 2002 DOI ScienceOn |
24 | Fu SY, Gordon T. The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14: 67−116, 1997 DOI ScienceOn |
25 | Guertin AD, Zhang DP, Mak KS, Alberta JA, Kim HA. Microanatomy of axon/glial signaling during Wallerian degeneration. J Neurosci 25: 3478−3487, 2005 DOI ScienceOn |
26 | Lee N, Neitzel KL, Devlin BK, MacLennan AJ. STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor. J Comp Neurol 474: 535−545, 2004 DOI ScienceOn |
27 | Thomson CE, Griffiths IR, McCulloch MC, Kyriakides E, Barrie JA, Montague P. In vitro studies of axonally-regulated Schwann cell genes during Wallerian degeneration. J Neurocytol 22, 590−602, 1993 DOI ScienceOn |
![]() |