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The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice  

Song, Ho-Sun (Department of Pathophysiology, College of Medicine, Chung-Ang University)
Park, Tae-Wook (Department of Pathophysiology, College of Medicine, Chung-Ang University)
Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, College of Medicine, Chung-Ang University)
Shin, Yong-Kyoo (Department of Pharmacology, College of Medicine, Chung-Ang University)
Choi, Byung-Chul (Department of Pathophysiology, College of Medicine, Chung-Ang University)
Kim, Chang-Jong (Department of Pathophysiology, College of Medicine, Chung-Ang University)
Sim, Sang-Soo (Department of Pathophysiology, College of Medicine, Chung-Ang University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.12, no.6, 2008 , pp. 343-347 More about this Journal
Abstract
This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase $A_2$ activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and $PGE_2$ production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.
Keywords
Caffeic acid; Histamine; Arachidonic acid; Collagen; Wound healing;
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Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
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