Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes
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Kong, Pil-Jae
(Department of Pharmacology, College of Medicine, Kangwon National University)
Byun, Jong-Seon (Department of Pharmacology, College of Medicine, Kangwon National University) Lim, So-Young (Department of Anesthesiology, College of Medicine, Hallym University) Lee, Jae-Jun (Department of Anesthesiology, College of Medicine, Hallym University) Hong, Sung-Jun (Department of Pharmacology, College of Medicine, Kangwon National University) Kwon, Kwang-Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Kangnung National University) Kim, Sung-Soo (Department of Pharmacology, College of Medicine, Kangwon National University) |
1 | Baecker PA, Lee WH, Verity AN, Eglen RM, Johnson RM. Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene. Brain Res Mol Brain Res 69: 209−222, 1999 |
2 | Boutin JA, Audinot V, Ferry G, Delagrange P. Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci 26: 412−419, 2005 |
3 | Castro LM, Gallant M, Niles LP. Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J Neurochem 95: 1227−1236, 2005 |
4 | Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273: 32377−32379, 1998 DOI ScienceOn |
5 | Musshoff U, Riewenherm D, Berger E, Fauteck JD, Speckmann EJ. Melatonin receptors in rat hippocampus: molecular and functional investigations. Hippocampus 12: 165−173, 2002 |
6 | Woodbury D, Schaar DG, Ramakrishnan L, Black IB. Novel structure of the human GDNF gene. Brain Res 803: 95−104, 1998 |
7 | Yano S, Tokumitsu H, Soderling TR. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396: 584−587, 1998 |
8 | Henshall DC, Araki T, Schindler CK, Lan JQ, Tiekoter KL, W TakiRP Simon. Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure- induced neuronal death. J Neurosci 22: 8458−8465, 2002 |
9 | Young D, Lawlor PA, Leone P, Dragunow M, During MJ. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 5: 448−453, 1999 |
10 | Conti AG, Maestroni J. The clinical neuroimmunotherapeutic role of melatonin in oncology. J Pineal Res 19: 103−110, 1995 |
11 | Tang YP, Ma YL, Chao CC, Chen KY, Lee EH. Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. J Neurosci Res 53: 593−604, 1998 |
12 | Maestroni GJ, Conti A, Pierpaoli W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 13: 19−30, 1986 |
13 | Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35: 697−709, 2002 |
14 | Lenhard T, Schober A, Suter-Crazzolara C, Unsicker K. Fibroblast growth factor-2 requires glial-cell-line-derived neurotrophic factor for exerting its neuroprotective actions on glutamate- lesioned hippocampal neurons. Mol Cell Neurosci 20: 181−197, 2002 |
15 | Kilic U, Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res 38: 67−71, 2005 |
16 | Lee SH, Chun W, Kong PJ, Han JA, Cho BP, Kwon OY, Lee HJ, Kim SS. Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus. J Pineal Res 40: 79−85, 2006 |
17 | Xu Q, Li Y, Cyras C, Sanan DA, Cordell B. Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle. J Biol Chem 275: 31770−31777, 2000 |
18 | Anhe GF, Caperuto LC, Pereira-Da-Silva M, Souza LC, Hirata AE, Velloso LA, Cipolla-Neto J, Carvalho CR. In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus. J Neurochem 90: 559−566, 2004 |
19 | 999Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401: 86−90, 1999 |
20 | Peters JL, Earnest BJ, Tjalkens RB, Cassone VM, Zoran MJ. Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific. J Comp Neurol 493: 370−380, 2005 |
21 | Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol Sci 17: 100−102, 1996 |
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