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Increased Rate of Palmitate Oxidation in Adults Female: Comparison with Peri-pubertal Young Female Rats  

Lee, Se-Young (Departments of Physiology, College of Medicine, Yeungnam University)
Kim, Jong-Yeon (Departments of Physiology, College of Medicine, Yeungnam University)
Kim, Yong-Woon (Departments of Physiology, College of Medicine, Yeungnam University)
Park, So-Young (Departments of Physiology, Aging-associated Vascular Disease Research Center, College of Medicine, Yeungnam University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.10, no.5, 2006 , pp. 283-287 More about this Journal
Abstract
Although estrogen is known to playa role in fatty acid metabolism, it remains unclear whether fatty acid oxidation in mature female rats differs from fatty acid oxidation in peri-pubertal young rats. In this study, we measured fatty acid metabolism in the skeletal muscles and livers of 5 and 50 weeks old male and female rats. The rate of palmitate oxidation in the liver and gastrocnemius red in the 50-week-old female rats were elevated as compared to the 5-week-old females, whereas there were no differences in the male rats. The rate of palmitate oxidation in the gastrocnemius red was correlated inversely with intra-abdominal fat mass in the 5-week-old male and female rats, whereas the palmitate oxidation rate was positively correlated with fat mass in the liver and gastrocnemius red in the 50-week-old rats. HOMA-IR and plasma insulin levels were positively correlated with intra-abdominal fat mass in the pooled 50-week-old male and female rats, but this correlation was not apparent in 5-week-old rats. In summary, the rate of fatty acid oxidation measured in the middle-aged adult female rats was significantly higher than those measured in the peri-pubertal young female rats. This difference may be attributed to the influence of ovarian hormones.
Keywords
Female; Intra-abdominal fat mass; Palmitate oxidation rate; Skeletal muscle;
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