Browse > Article

Sweating by Exercise Controls Body Temperature through Increase of Interleukin-1beta  

Bae, Jun-Sang (Department of Physiology, College of Medicine, Soonchunhyang University)
Shin, Young-Oh (Department of Physiology, College of Medicine, Soonchunhyang University)
Lee, Jeong-Beom (Department of Physiology, College of Medicine, Soonchunhyang University)
Seok, Hyun (Department of Physiology, College of Medicine, Soonchunhyang University)
Min, Young-Ki (Department of Physiology, College of Medicine, Soonchunhyang University)
Yang, Hun-Mo (Department of Physiology, College of Medicine, Soonchunhyang University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.10, no.5, 2006 , pp. 231-234 More about this Journal
Abstract
This study was designed to investigate the expression and production of interleukin-1beta $(IL-1{\beta})$ in human peripheral blood of trained runners and untrained controls after temporary moderate intensity exercise. Male long-distance trained runners (TR) and untrained sedentary control subjects (SED) ran for 1 h at 70% of heart rate reserve (HRR). $IL-1{\beta}$ gene and protein expressions were significantly higher in TR than those with SED at all 3 intervals examined independently. Significant increases in total sweat volume and oral temperature were observed after exercise in both groups, however, there were some differences between the groups. We conclude, therefore, that sweating due to exercise is associated with increase of $IL-1{\beta}$ and it is correlated with decrease of oral temperature.
Keywords
Sweating; Exercise; Body temperature; Interleukin-1beta; Trained runner;
Citations & Related Records

Times Cited By SCOPUS : 1
연도 인용수 순위
1 Bordin JO, Heddle NM, Blajchman MA. Biologic effects of leukocytes present in transfused cellular blood products. Blood 84: 1703-1721, 1994
2 Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol 76: 505- 511, 1998   DOI   ScienceOn
3 Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, Young AJ, Shek PN. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. Am J Physiol Regul Integr Comp Physiol 281: R66-R75, 2001   DOI
4 Schimidt JA, Abdulla E. Down-regulation of IL-1b biosynthesis by inducers of the heat shock response. J Immunol 141: 2027- 2034, 1988
5 Thorpe R, Wadhwa M, Bird CR, Mire-Sluis AR. Detection and measurement of cytokines. Blood Rev 6: 133-148, 1992   DOI   ScienceOn
6 Turnbull AV, Rivier CL. Regulation of the hypothalamic-pituitaryadrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79: 1-71, 1999   DOI
7 Wadhwa M, Seghatchian MJ, Lubenko A, Contreras M, Dilger P, Bird C, Thorpe R. Cytokine levels in platelet concentrates: quantitation by bioassays and immunoassays. Br J Haematol 93: 225- 234, 1996   DOI   ScienceOn
8 Westwood JT, Clos J, Wu C. Stress-induced oligomerization and chromosomal relocalization of heat-shock factor. Nature 353: 822- 827, 1991   DOI   ScienceOn
9 Shin YO, Oh JK, Sohn HS, Bae JS, Lee MY, Lee JB, Yang HM, Min YK, Song HY, Ko KK, Matsumoto T. Expression of exerciseinduced HSP70 in long-distance runner's leukocytes. J Therm Biol 29: 769-774, 2004   DOI   ScienceOn
10 Wu C, Zimarino V, Tsai C, Walker B, Wilson S. Transcriptional regulation of heat shock genes. In: Morimoto RI, Tissieres A, Georgopulos C ed, Stress Proteins In Biology And Medicine. 1st ed. Cold Spring Harbor Laboratory Press, NY, p 429-442, 1990
11 Baumann H, Gauldie J. The acute phase response. Immunol Today 15: 74-80, 1994   DOI   ScienceOn
12 Drenth JP, Van Uum SH, Van Deuren M, Pesman GJ, Van der Ven-Jongekrijg J, Van der Meer JW. Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF- alpha and IL-1 beta production. J Appl Physiol 79: 1497-1503, 1995   DOI
13 Armstrong LE, Maresh CM. The induction and decay of heat acclimatisation in trained athletes. Sports Med 12: 302-312, 1991   DOI   ScienceOn
14 Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res 10: 201- 222, 2004
15 Wyndham CH, Rogers GG, Senay LC, Mitchell D. Acclimization in a hot, humid environment: cardiovascular adjustments. J Appl Physiol 40: 779-785, 1976   DOI
16 DeRijk R, Michelson D, Karp B, Petrides J, Galliven E, Deuster P, Paciotti G, Gold PW, Sternberg EM. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. J Clin Endocrinol Metab 82: 2182-2191, 1997   DOI   ScienceOn
17 Moldoveanu AI, Shephard RJ, Shek PN. Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. J Appl Physiol 89: 1499-1504, 2000   DOI
18 Rivier A, Pene J, Chanez P, Anselme F, Caillaud C, Prefaut C, Godard P, Bousquet J. Release of cytokines by blood monocytes during strenuous exercise. Int J Sports Med 15: 192-198, 1994   DOI   ScienceOn
19 Weinstock C, Konig D, Harnischmacher R, Keul J, Berg A, Northoff H. Effect of exhaustive exercise stress on the cytokine response. Med Sci Sports Exerc 29: 345-354, 1997   DOI   ScienceOn
20 Cohen MC, Cohen S. Cytokine function: a study in biologic diversity. Am J Clin Pathol 105: 589-598, 1996   DOI
21 Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin- 6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25: 1813-1819, 1997   DOI   ScienceOn
22 Buono MJ, Heaney JH, Canine KM. Acclimation to humid heat lowers resting core temperature. Am J Physiol 274: R1295-R1299, 1998
23 Karvonen MJ, Kentala E, Mustala O. The effect of training on heart rate: a longitudinal study. Ann Med Exp Biol Fenn 35: 307-315, 1957
24 Dinarello CA. The biological properties of interleukin-1. Eur Cytokine Netw 5: 517-531, 1994
25 Knudsen PJ, Dinarello CA, Strom TB. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol 137: 3189-3194, 1986
26 Sprenger H, Jacobs C, Nain M, Gressner AM, Prinz H, Wesemann W, Gemsa D. Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clin Immunol Immunopathol 63: 188-195, 1992   DOI   ScienceOn
27 Bagby GJ, Crouch LD, Shepherd RE. Exercise and cytokines: spontaneous and elicited responses. In: Hoffman-Goetz L ed, Exercise and Immune Function. 1st ed. CRC, Boca Raton, FL, p 55-77, 1996