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The Improvement of Learning and Memory Ability of Normal Persons by BF-7  

Lee, Sang-Hyung (Department of Neurosurgery, College of Medicine, Seoul National University)
Kim, Yong-Sik (Department of Pharmacology, College of Medicine, Seoul National University)
Kang, Yong-Koo (Department of Anatomy, College of Medicine, Chung-Ang University)
Kwon, Oh-Sang (Department of Neurology, College of Medicine, Chung-Ang University)
Shin, Yong-Kyoo (Department of Pharmacology, College of Medicine, Chung-Ang University)
Song, Jln-Ho (Department of Pharmacology, College of Medicine, Chung-Ang University)
Lee, Moo-Yeol (Department of Physiology, College of Medicine, Chung-Ang University)
Lee, Kwang-Gill (Applied Entomology Division, Department of Sericulture and Entomology, National Institute of Agriculture Science Technology)
Yeo, Joo-Hong (Applied Entomology Division, Department of Sericulture and Entomology, National Institute of Agriculture Science Technology)
Lee, Won-Bok (Department of Anatomy, College of Medicine, Chung-Ang University)
Lee, Tae-Jin (Department of Pathology, College of Medicine, Chung-Ang University)
Kim, Sung-Su (Department of Anatomy, College of Medicine, Chung-Ang University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.8, no.6, 2004 , pp. 307-312 More about this Journal
Abstract
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-T plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
Keywords
Brain; Learning and memory; BF-7; Acetylcholine; Neuroprotection;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 5
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