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Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity in Rat Atrial Myocytes  

Youm, Jae-Boum (Department of Physiology, Cheju National University College of Medicine)
Jo, Su-Hyun (Department of Physiology, Cheju National University College of Medicine)
Leem, Chae-Hun (Department of Physiology and the Institute for Calcium Research, University of Ulsan College of Medicine)
Ho, Won-Kyung (Department of Physiology and Biophysics, Seoul National University College of Medicine)
Earm, Yung E. (Department of Physiology and Biophysics, Seoul National University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.8, no.1, 2004 , pp. 33-41 More about this Journal
Abstract
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels, pumps, exchangers, and changes of intracellular ion concentration. Changes in membrane excitability and $Ca^{2+}$ transients could then be calculated. In the model, the major ion channels responsible for the stretch-induced changes in electrical activity were the stretch-activated channels (SACs). The relationship between the extent of stretch and activation of SACs was formulated based on the experimental findings. Then, the effects of mechanical stretch on the electrical activity were reproduced. The shape of the action potential (AP) was significantly changed by stretch in the model simulation. The duration was decreased at initial fast phase of repolarization (AP duration at 20% repolarization level from 3.7 to 2.5 ms) and increased at late slow phase of repolarization (AP duration at 90% repolarization level from 62 to 178 ms). The resting potential was depolarized from -75 to -61 mV. This mathematical model of SACs may quantitatively predict changes in cardiomyocytes by mechanical stretch.
Keywords
Stretch-activated channels; Mechanical stretch; Atrial myocyte;
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