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Curcumin Attenuates Gliall Cell Activation But Cannot Suppress Hippocampal CA3 Neuronal Cell Death in i.c.v. Kanic Acid Injection Model  

Cho, Jae-Young (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University)
Kong, Pil-Jae (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University)
Chun, Wan-Joo (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University)
Moon, Yeo-Ok (Department of Pharmacology, College of Medicine ,Medical Science Research Institute, Kangwon National University)
Park, Yee-Tae (Department of Neuroscience, Medical Science Research Institute, Kangwon National University)
Lim, So-Young (Department of Anesthesiology, College of Medicine, Hallym University)
Kim, Sung-Soo (Department of Pharmacology, College of Medicine and Department of Neuroscience, Medical Science Research Institute, Kangwon National University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.7, no.6, 2003 , pp. 307-310 More about this Journal
Abstract
Kainic acid (KA) is a structural analogue of glutamate that interacts with specific presynaptic and postsynaptic receptors to potentiate the release and excitatory actions of glutamate. Systemic or intracerebroventricular (i.c.v.) administration of KA to experimental animals elicits multifocal seizures with a predominantly limbic localization, and results in neuronal death of cornu ammonia 1 (CA1), reactive gliosis and biochemical changes in the hippocampus and other limbic structures. Several lines of evidence suggest that reactive oxygen species (ROS) play a pivotal role in the pathogenesis of excitotoxic death by KA. Curcumin has been known to possess anti-oxidative and anti-inflammatory activities. In this study, the effects of curcumin on KA induced hippocampal cell death, reactive gliosis and biochemical changes in reactive glia were investigated by immunohistochemical methods. Our data demonstrated that curcumin attenuated KA-induced astroglial and microglial activation although it did not protect KA-induced hippocampal cell death.
Keywords
Curcumin; Kanic acid; Glial activation; Astrocyte; Microglia;
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