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Expression Profiles of Immune-related Genes in Fluoxetine-treated Human Mononuclear Cells by cDNA Microarray  

Lee, Hee-Jae (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Jin, Sheng-Yu (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Hong, Mee-Suk (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Li, Guang-Zhe (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Kim, Jong-Woo (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Kim, Beom-Sik (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Chung, Joo-Ho (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.7, no.5, 2003 , pp. 279-282 More about this Journal
Abstract
To investigate the effect of fluoxetine, one of selective serotonin reuptake inhibitors (SSRIs), on the immune system, human peripheral blood mononuclear cells (PBMC) were treated with fluoxetine $(10^{-7}\;M)$ for 24 h, and immune-related genes were analyzed by cDNA microarray. Expression of the immunerelated genes such as CD107b (LAMP-2), CD47 receptor (thrombospondin receptor), CD5 antigen-like (scavenger receptor cysteine rich family), copine III (CPNE3), interleukin (IL)-18 (interferon-gammainducing factor), integrin alpha 4 (CD49d), integrin alpha L subunit (CD11a), IL-3 receptor alpha subunit, L apoferritin, and small inducible cytokine subfamily A (Cys-Cys) member 13 (SCYA13) was induced by fluoxetine. This result suggests that fluoxetine may affect the immune system, and provides fundamental data for the involvement of SSRIs on immunoregulation.
Keywords
Fluoxetine,; Immune system; cDNA microarray; Peripheral blood mononuclear cell (PBMC);
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