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Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney  

Lee, Jong-Un (Department of Physiology, Chonnam National University Medical School)
Yoo, Kwang-Jay (Department of Physiology, Seonam National University College of Medicine)
Oh, Yoon-Wha (Department of Physiology, Chonnam National University Medical School)
Lim, Dong-Yoon (Department of Pharmacology, Chosun National University Medical College)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.7, no.3, 2003 , pp. 181-185 More about this Journal
Abstract
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found significantly decreased following the denervation. Accordingly, the expression of AQP2 proteins was markedly decreased. The expression of AQP3 and AQP4 was also slightly but significantly decreased, while that of AQP1 was not. Neither the basal nor the AVP-stimulated accumulation of cAMP was significantly affected in the denervated kidney. It is suggested that the sympathetic nervous system has a tonic stimulatory effect on AQP channels in the kidney.
Keywords
Aquaporins; Sympathetic nervous system; Kidney;
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