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Selective Cytotoxicity of Novel Platinum(II) Coordination Complexes on Human Bladder Cancer Cell-Lines and Normal Kidney Cells  

Kim, Jung-Tae (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
Rho, Young-Soo (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
Jung, Jee-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.7, no.2, 2003 , pp. 111-117 More about this Journal
Abstract
Cisplatin is often effective in cancer treatment, but its clinical use is limited because of its nephrotoxicity. We have synthesized new platinum(II) coordination complexes (PC-1 & PC-2) containing trans-${\iota}$ and cis-1,2-diaminocyclohexane (DACH) as carrier ligands and L-3 -phenyllactic acid (PLA) as a leaving group with the aim of reducing nephrotoxicity but maintaining its anticancer activity. In this study, new platinum(II) complex compounds were evaluated for selective cytotoxicity on cancer cell-lines and normal kidney cells. The new platinum complexes have demonstrated high efficacy in the cytotoxicity against human bladder carcinoma cell-lines (T-24/HT-1376). The cytotoxicity of these compounds against rabbit proximal renal tubular cells and human renal cortical tissues, was determined by MTT assay, the [3H]-thymidine uptake and glucose consumption test, and found to be quite less than those of cisplatin. Based on our results, these novel platinum compounds appear to be valuable lead compounds with high efficacy and low nephrotoxicity.
Keywords
Selective cytotoxicity; Platinum(II) complex; Human bladder carcinoma cells; Normal kidney cells;
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