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Apo-1/Fas (CD95) Gene Polymorphism in Korean Hepatocellular Carcinoma Patients  

Kim, Sung-Soo (Department of Pharmacology, College of Medicine, Kangwon National University)
Hong, Seung-Jae (Division of Rheumatology, Department of Internal Medicine, College of Medicine, KyungHee University)
Ahn, Yun-Gul (Department of Pharmacology, College of Medicine, Kangwon National University)
Kim, Bong-Seog (Department of Pharmacology, College of Medicine, Kangwon National University,Division of Hemato- oncology, Department of Internal Medicine, Seoul Veterans Hospital)
Yuh, Young-Jin (Department of Pharmacology, College of Medicine, Kangwon National University,Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University)
Han, Kye-Young (Department of Orthopaedic Surgery, College of Medicine, Kangwon National University)
Lee, Hee-Jae (Kohwang Medical Research Institute, College of Medicine, Kyung Hee University)
Chung, Joo-Ho (Kohwang Medical Research Institute, College of Medicine, Kyung Hee University)
Yim, Sung-Vin (Department of Pharmacology, College of Medicine, Kangwon National University)
Cho, Jae-Young (Department of Anatomy, College of Medicine, Seoul National University)
Park, Yeon-Hee (Division of Medical Oncology, Korea Cancer Center Hospital)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.7, no.1, 2003 , pp. 29-31 More about this Journal
Abstract
It is well known that different expression of Apo-1/Fas (CD95) plays important roles in various tumors and hepatocellular carcinoma (HCC) pathogenesis. Apo-1/Fas mediated apoptosis is one of the important pathways of apoptosis and is known to mediate apoptotic cell death by fas ligand (FasL). To examine the possible relationship between Apo-1/Fas gene polymorphism and HCC susceptibility, MvaI restriction fragment length polymorphism (RFLP) of Apo-1/Fas gene was examined in 94 Korean HCC patients and 240 control subjects. No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the HCC. It is, therefore, concluded that Apo-1/Fas gene polymorphism is not associated with HCC susceptibility. Further studies are needed in order to clarify the relationships between genotypes of Apo-1/Fas gene and HCC pathogenesis.
Keywords
Hepatocellular carcinoma; Apo-1/Fas (CD95); Polymorphism; PCR-RFLP; Apoptosis;
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