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Renal Tubular Acidosis in Cadmium-Intoxicated Rats  

Ahn, Do-Whan (Department of Physiology, Kosin University College of Medicine)
Kim, Kyoung-Ryong (Department of Physiology, Kosin University College of Medicine)
Choi, Jang-Kyu (Department of Physiology, Kosin University College of Medicine)
Park, Yang-Saeng (Department of Physiology, Kosin University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.6, no.1, 2002 , pp. 41-46 More about this Journal
Abstract
Effect of cadmium (Cd) intoxication on renal acid-base regulation was studied in adult male Sprague-Dawley rats. Cd intoxication was induced by subcutaneous injections of $CdCl_2$ at a dose of 2 mg Cd/kg/day for $3{\sim}4$ weeks. In Cd-intoxicated animals, arterial pH, $PCO_2$ and plasma bicarbonate concentration decreased, showing a metabolic acidosis. Urine pH and urinary bicarbonate excretion increased and titratable acid excretion decreased with no change in ammonium excretion. In renal cortical brush-border membrane vesicles derived from Cd-exposed animals, the $Na^+/H^+$ antiporter activity was significantly attenuated. These results indicate that chronic exposures to Cd impair the proximal tubular mechanism for $H^+$ secretion (i.e., $Na^+/H^+$ antiport), leading to a metabolic acidosis.
Keywords
Cadmium; Kidney; Acid-base;
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