Browse > Article
http://dx.doi.org/10.17480/psk.2016.60.3.141

Study on Lifespan Extension Effect of Leonurine and its Synthetic Fragmental Analogs on Caenorhabditis elegans  

Cha, Dong Seok (College of Pharmacy, Woosuk University)
Han, Young Taek (College of Pharmacy, Dankook University)
Publication Information
YAKHAK HOEJI / v.60, no.3, 2016 , pp. 141-145 More about this Journal
Abstract
The current study was conducted to evaluate the lifespan extension effects of leonurine and its synthetic fragmental analogs using Caenohabditis elegans model system. Leonurine significantly prolonged the lifespan of C. elegans in a dose-dependent manner. To dissect the structure-activity relationship between leonurine and lifespan extension activity, seven novel fragmental analogs were synthesized and evaluated. Our study revealed that benzoate part of leonurine is responsible for its lifespan extension property rather than quanidine moiety.
Keywords
leonurine; lifespan extension; synthesis; fragmental analog; Caenorhabditis elegans; structure-activity relationship;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bokov, A., Chaudhuri, A. and Richardson, A. : The role of oxidative damage and stress in aging. Mech. Ageing Dev. 125, 811 (2004).   DOI
2 Peng, C., Wang, X., Chen, J., Jiao, R., Wang, L., Li, Y. M., Zuo, Y., Liu, Y., Lei, L., Ma, K. Y., Huang, Y. and Chen, Z. Y. : Biology of ageing and role of dietary antioxidants. Biomed. Res. Int. 2014, 831841 (2014).
3 Sadowska-Bartosz, I. and Bartosz, G. : Effect of antioxidants supplementation on ageing and longevity. Biomed. Res. Int. 2014, 404680 (2014).
4 Yeung, H. W., Kong, Y. C., Lay, W. P. and Cheng, K. F. : The structure and biological effect of leonurine. A uterotonic principle from the Chinese drug, I-mu Ts'ao. Planta Med. 31, 51 (1977).   DOI
5 Loh, K. P., Tan, B. K., Liu, X. H., Wei, X. H. and Zhu, Y. Z. : Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function. Stroke 41, 2661 (2010).   DOI
6 Liu, C., Guo, W., Shi. X., Kaium, M. A., Gu, X. and Zhu, Y. Z. : Leonurine-cysteine analog conjugates as a new class of multifuntional anti-myocardial ischemia agent. Eur. J. Med. Chem. 46, 2996 (2011).
7 Sugiura, S., Inoue, S., Hayashi, Y., Kishi, Y. and Goto, T. : structure and synthesis of leonurine. Tetrahedron 25, 5155 (1969).   DOI