1 |
Kaplowitz, N. : Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4, 489 (2005).
DOI
|
2 |
Guengerich, F. P. and MacDonald, J. S. : Applying mechanisms of chemical toxicity to predict drug safety. Chem. Res. Toxicol. 20, 344 (2007).
DOI
|
3 |
Park, B. K., Kitteringham, N. R., Maggs, J. L., Pirmohamed, M. and Williams, D. P. : The role of metabolic activation in druginduced hepatotoxicity. Annu. Rev. Pharmacol. Toxicol. 45, 177 (2005).
DOI
|
4 |
Donato, M. T., Lahoz, A., Castell, J. V. and Gomez-Lechon, M. J. : Cell lines: a tool for in vitro drug metabolism studies. Curr. Drug Metab. 9, 1 (2008).
DOI
|
5 |
Guillouzo, A. : Liver cell models in in vitro toxicology. Environ. Health Perspect. 106 Suppl. 2, 511 (1998).
DOI
|
6 |
Aninat, C., Piton, A., Glaise, D., Le Charpentier, T., Langouet, S., Morel, F., Guguen-Guillouzo, C. and Guillouzo, A. : Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab. Dispos. 34, 75 (2006).
|
7 |
Doehmer, J., Dogra, S., Friedberg, T., Monier, S., Adesnik, M., Glatt, H. and Oesch, F. : Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1. Proc. Natl. Acad. Sci. U.S.A. 85, 5769 (1988).
DOI
|
8 |
Gomez-Lechon, M. J., Donato, T., Jover, R., Rodriguez, C., Ponsoda, X., Glaise, D., Castell, J. V. and Guguen-Guillouzo, C. : Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. Eur. J. Biochem. 268, 1448 (2001).
DOI
|
9 |
Hosomi, H., Fukami, T., Iwamura, A., Nakajima, M. and Yokoi, T. : Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation. Drug Metab. Dispos. 39, 1388 (2011).
DOI
|
10 |
Choi, J. M., Oh, S. J., Lee, J. Y., Jeon, J. S., Ryu, C. S., Kim, Y. M., Lee, K. H. and Kim, S. K. : Prediction of drug-induced liver injury in HepG2 cells cultured with human liver microsomes. Chem. Res. Toxicol. 28, 872 (2015).
DOI
|
11 |
Mosmann, T. : Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55 (1983).
DOI
|
12 |
Lee, K. S. and Kim, S. K. : Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. J. Appl. Toxicol. 33, 100 (2013).
DOI
|
13 |
Smith, M. T. : Mechanisms of troglitazone hepatotoxicity. Chem. Res. Toxicol. 16, 679 (2003).
DOI
|
14 |
Ikeda, T. : Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case. Drug Metab. Pharmacokinet. 26, 60 (2011).
DOI
|
15 |
Graham, E. E., Walsh, R. J., Hirst, C. M., Maggs, J. L., Martin, S., Wild, M. J., Wilson, I. D., Harding, J. R., Kenna, J. G., Peter, R. M., Williams, D. P. and Park, B. K. : Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. J. Pharmacol. Exp. Ther. 326, 657 (2008).
DOI
|
16 |
Howell, B. A., Yang, Y., Kumar, R., Woodhead, J. L., Harrill, A. H., Clewell, H. J., 3rd, Andersen, M. E., Siler, S. Q. and Watkins, P. B. : In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym: a mechanistic, mathematical model of DILI. J. Pharmacokinet. Pharmacodyn. 39, 527 (2012).
DOI
|