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http://dx.doi.org/10.17480/psk.2015.59.4.184

Serotonin as a Possible Modulator of Impulsive Behavior in Wistar Rats  

Kim, Chong Ah (Uimyung Research Institute for Neuroscience, Sahmyook University)
Cheong, Jae Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
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YAKHAK HOEJI / v.59, no.4, 2015 , pp. 184-189 More about this Journal
Abstract
We compared impulsive behaviors in Wistar rats and in Wistar-Kyoto rats. There was no significant difference in locomotor activity between them. However, Wistar rats showed high activity in 5-choice serial reaction time track. When Wistar rats were treated with atomoxetin (3 mg/kg), methylphenidate (2 mg/kg) or amphetamine (2 mg/kg), they showed less impulsive behavior. Serotonin contents in prefrontal cortex and brain stem also increased. In conclusion, we suggest that Wistar rats could be used as animal model for impulsive behavior analysis. In addition, serotonin might be related with this impulsivity.
Keywords
Wistar rat; WKY; impulsivity; locomotor activity; serotonin;
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