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http://dx.doi.org/10.17480/psk.2015.59.2.66

Concise Synthesis of Flurbiprofen via Palladium-Catalyzed Cross-Coupling Reactions  

Han, Young Taek (College of Pharmacy, Dankook University)
Publication Information
YAKHAK HOEJI / v.59, no.2, 2015 , pp. 66-69 More about this Journal
Abstract
A concise synthesis of flurbiprofen, a member of the non-steroidal anti-inflammatory 2-arylpropionic acids, has been accomplished. The key feature of this synthesis involves successive palladium-catalyzed cross coupling reactions. In particular, a 2-arylacylate intermediate, which easily converted to the key 2-arylpropionic acid scaffold, was afforded by a versatile palladium-catalyzed cross coupling reaction between diazopropanate and bisphenylboronic acid. This synthetic procedure would facilitate synthesis of the flurbiprofen and anti-inflammatory 2-arylpropionic acid derivatives.
Keywords
flurbiprofen; synthesis; 2-arylpropionic acid; palladium catalyzed cross-coupling; diazo compound;
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