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http://dx.doi.org/10.17480/psk.2015.59.2.55

Synthesis and NF-κB Inhibitory Activities of N-Substituted-aryl-3-phenylpropanamide Derivatives  

Choi, Minho (College of Pharmacy, Chungbuk National University)
Kim, Youngsoo (College of Pharmacy, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University)
Lee, Heesoon (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.59, no.2, 2015 , pp. 55-58 More about this Journal
Abstract
A series of N-substitutedaryl-3-phenylpropanamide derivatives were synthesized and their inhibitory activities on LPS-induced NF-$1{\kappa}B$ transcriptional activity on RAW 264.7 cells were evaluated. Cl substituted derivatives (1e, 1f) have shown more potent activities than parent hit compound KL-1156.
Keywords
NF-$1{\kappa}B$; KL-1156; N-substitutedaryl-3-phenylpropanamide derivatives;
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