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Effect of Chamomile Flower Extract on Septic Arthritis due to Candida albicans  

Kim, Jeonghyeon (College of Pharmacy, Dongduk Women's University)
Kim, Songyi (National Institute of Food and Drug Safety Evaluation)
Hong, Yuna (College of Pharmacy, Seoul National University)
Kim, Yeong Shik (College of Pharmacy, Seoul National University)
Han, Yongmoon (College of Pharmacy, Dongduk Women's University)
Publication Information
YAKHAK HOEJI / v.58, no.5, 2014 , pp. 343-348 More about this Journal
Abstract
In the present studies, we examined effect of chamomile flowers extract (CH-Ex), which has traditionally been used as antiphlogistics in Europe for many centuries, against Candida albicans-caused septic arthritis. Candida albicans is a major etiological agent among fungal septic arthritis. This effect was investigated in a murine model of the septic arthritis. That is, mice that were given an emulsion form of C. albicans cell wall (CACW) via footpad route were treated intraperitoneally with the CH-Ex for 3 times every 3 days. Degrees of the footpad-swellings were measured with dial gauger. Data showed that the CH-Ex resulted in the reduction of swelling. For instance, at Day 9 when swelling reached the highest peak, there was up to app. 60% reduction of edema in mice injected with the CH-Ex, compared to that of the control mice that received no treatment (P<0.05). This therapeutic anti-arthritic activity appeared to be mediated by inhibitions of NO (nitric oxide) production from activated RAW264.7 macrophages and proliferation of Con A-treated T lymphocytes. Analysis by HPLC revealed that the CH-Ex contained eight polyphenolic compounds including chlorogenic acid (CRA) and rutin. We have reported the CRA and rutin respectively have the anti-arthritic activity. This correlation implicates that CRA and rutin in the CH-Ex may be responsible for the activity. Combined all together, the CH-Ex has anti-arthritic activity against C. albicans-caused septic arthritis, possibly by inhibiting NO production and proliferation of T cells. This activity seems to be contributed by, at least, CRA and rutin among the compounds in the CH-Ex.
Keywords
chamomille flowers extract; Candida albicans; septic arthritis; macrophage; T lymphocyte; chlorogenic acid; rutin;
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1 Cuende, E., Barbadillo, C. E., Mazzucchelli, R., Isasi, C., Trujillo, A. and Andreu, J. L. : Candida arthritis in adult patients who are not intravenous drug addicts: report of three cases and review of the literature. Semin Arthritis Rheum. 22, 224 (1993).   DOI   ScienceOn
2 Lerch, K., Kalteis, T., Schubert, T., Lehn, N. and Grifka, J. : Prosthetic joint infection with osteomyelitis due to Candida albicans. Mycoses. 46, 462 (2003).   DOI   ScienceOn
3 Azaceta, G., Olave. T., de los Martires, L. D., Delgado, C., Gutierrez, M. and Palomera, L. : Successful lipid-complexed amphotericin B treatment of Candida arthritis in a lymphoma patient. Rev. Rhum. Engl. 66, 434 (1999).
4 Choi, I. S., Kim, S. J., Kim, B. Y., Joh, J. W., Kim, Y. I., Lee, S. K., Huh, W. S., Oh, H. Y., Kim, D. J., Kim, Y. G., Kim, M. K., Ko, Y. H. and Lee, B. B. : Candida polyarthritis in a renal transplant patient: case report of a patient successfully treated with amphotericin B. Transplant Proc. 32, 1963 (2000).   DOI   ScienceOn
5 Lee, D. M. and Weinblatt, M. E. : Rheumatoid arthritis. Lancet. 358, 903 (2001).   DOI   ScienceOn
6 Felson, D. T., Anderson, J. J. and Meena, R. F. : Use of shortterm efficacy/toxicity tradeoffs to select second-line drugs in rheumatoid arthritis: a metaanalysis of published clinical trials. Arthritis Rheum. 35, 1117 (1992).   DOI   ScienceOn
7 Bauer, H. and Marker-Hermann, E. : Therapy with nonsteroidal anti-inflammatory drugs. Orthopade. 32, 1088 (2003).   DOI   ScienceOn
8 Drummond, E. M., Harbourne, N., Marete, E., Martyn, D., Jacquier, J., O'Riordan, D. and Gibney, E. R. : Inhibition of proinflammatory biomarkers in THP macrophages by polyphenols derived from chamomile, meadowsweet and willow bark. Phytother Res. 27, 588 (2013).   DOI   ScienceOn
9 Taliou, A., Zintzaras, E., Lykouras, L. and Francis, K. : An open-label pilot study of a formulation containing the antiinflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther. 35, 592 (2013).   DOI   ScienceOn
10 Bhaskaran, N., Srivastava, J. K., Shukla, S. and Gupta, S. : Chamomile confers protection against hydrogen peroxideinduced toxicity through activation of Nrf2-mediated defense response. Phytother Res. 27, 118 (2013).   DOI   ScienceOn
11 Kagawa, D., Jokura, H., Ochiai, R., Tokimitsu, I. and Tsubone, H. : The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation. Planta Med. 69, 637 (2003).   DOI   ScienceOn
12 Abebe, W. : Herbal medication: potential for adverse interactions with analgesic drugs. J. Clin. Pharm. Ther. 27, 391 (2002).   DOI   ScienceOn
13 Weidner, C., Wowro, S. J., Rousseau, M., Freiwald, A., Kodelja, V., Abdel-Aziz, H., Kelber, O. and Sauer S. : Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family. PLoS One. 8, e80335 (2013).   DOI
14 McKay, D. L. and Blumberg, J. B. : A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res. 20, 519 (2006).   DOI   ScienceOn
15 Trouillas, P., Calliste, C. A., Allais, D. P., Simon, A., Marfak, A., Delage, C. and Duroux, J. L. : Antioxidant, antiinflammatory and antiproliferative properties of sixteen water plant extracts used in the Limousin countryside as herbal teas. Food Chem. 80, 399 (2003).   DOI   ScienceOn
16 Han, Y. : Rutin has therapeutic effect on septic arthritis caused by Candida albicans. Int. Immunopharmacol. 9, 207 (2009).   DOI   ScienceOn
17 Mueller, M., Hobiger, S. and Jungbauer, A. : Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem. 122, 987 (2010).   DOI   ScienceOn
18 Han, Y. : Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritis. Int. Immunopharmacol. 5, 1049 (2005).   DOI   ScienceOn
19 Lee, J. H., Park, J. H., Kim, Y. S. and Han, Y. : Chlorogenic acid, a polyphenolic compound, treats mice with septic arthritis caused by Candida albicans. Int. Immunopharmacol. 8, 1681 (2008).   DOI   ScienceOn
20 Kinne, R. W., Brauer, R., Stuhlmuller, B., Palombo-kinne, E. and Burmester, G.-R. : Macrophages in rheumatoid arthritis. Arthritis Res. 2, 189 (2000).   DOI   ScienceOn
21 Nissler, K., Pohlers, D., Huckel, M., Simon, J., Brauer, R. and Kinne, R. W. : Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation. Ann. Rheum. Dis. 63, 1470 (2004).   DOI   ScienceOn
22 Paniagua, R. T., Sharpe, O., Ho, P. P., Chan, S. M., Chang, A., Higgins, J. P., Tomooka, B. H., Thomas, F. M., Song, J. J., Goodman, S. B., Lee, D. M., Genovese, M. C., Utz, P. J., Steinman, L. and Robinson, W. H. : Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune. J. Clin. Invest. 116, 2633 (2006).   DOI   ScienceOn
23 Colic, M., Vucevic, D., Kilibarda, V., Radicevic, N. and Savic, M. : Modulatory effects of garlic extracts on proliferation of Tlymphocytes in vitro stimulated with concanavalin A. Phytomedicine. 9, 117 (2002).   DOI   ScienceOn
24 Gao, X., Deeb, D., Media, J., Divine, G., Jiang, H., Chapman, R. A. and Gautam, S. C. : Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochem. Pharmacol. 66, 2427 (2003).   DOI   ScienceOn
25 Ranjan, D., Chen, C., Johnston, T. D., Jeon, H. and Nagabhushan, M. : Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling. J. Surg. Res. 121, 171 (2004).   DOI   ScienceOn
26 Kim, J., Joo, I., Kim, H. and Han, Y. : $18{\beta}$-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract. Phytomedicine. 20, 951 (2013).   DOI   ScienceOn
27 Han, Y. and Cutler, J. E. : Antibody response that protects against disseminated candidiasis. Infect Immun. 63, 2714 (1995).
28 Han, Y., Kozel, T. R., Zhang, M. X., MacGill, R. S., Carroll, M. C. and Cutler, J. E. : Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis. J. Immunol. 167, 1550 (2001).   DOI
29 Han, Y., Ulrich, M. A. and Cutler, J. E. : Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis. J. Infect. Dis. 179, 1477 (1999).   DOI   ScienceOn
30 Lotito, A. P., Muscara, M. N., Kiss, M. H., Teixeira, S. A., Novaes, G. S., Laurindo, I. M., Silva, C. A. and Mello, S. B. : Nitric oxide-derived species in synovial fluid from patients with juvenile idiopathic arthritis. Rheumatol. 31, 992 (2004).
31 Pohlers, D., Nissler, K., Frey, O., Simon, J., Petrow, P. K., Kinne, R. W. and Brauer, R. : Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation. Clin. Exp. Immunol. 135, 409 (2004).   DOI   ScienceOn