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Anti-platelet Effects of Mixtures of Onion and Aloe Extract  

Lee, Bo Kyung (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon)
Lee, Do-Seop (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon)
Ha, Soyoung (Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University)
Park, Se Won (Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University)
Jung, Yi-Sook (Department of Pathphysiology, College of Pharmacy, Ajou University of Suwon)
Publication Information
YAKHAK HOEJI / v.58, no.5, 2014 , pp. 322-327 More about this Journal
Abstract
In this study, we investigated whether the mixtures of onion water extract and aloe ethanol extracts have antiplatelet activities. The mixtures inhibited collagen- and thrombin-induced rat platelet aggregation in vitro. Additionally, the oral administration of the mixtures inhibited platelet aggregation induced by collagen ex vivo but not prolonged mouse tail vein bleeding time in vivo. These results suggest that the combination of onion and aloe extracts has a potential to be a preventive agent against platelet-mediated disorders.
Keywords
platelet aggregation; onion; aloe; blood coagulation; thromboxane;
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