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The Regulatory Role of Chenodeoxycholic Acid on the Proliferation of Osteoclast Precursor Cells  

Noh, A Long Sae Mi (College of Pharmacy, Sookmyung Women's University)
Yim, Mijung (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.58, no.3, 2014 , pp. 165-170 More about this Journal
Abstract
We investigated the effect of Chenodeoxycholic acid (CDCA) on the proliferation of osteoclast precursor cells. CDCA decreased the proliferation of osteoclast precursor cells through the control of cell cycle regulators such as cyclin D1, p21 and p27. When we checked the signaling pathway, CDCA decreased Erk activation in osteoclast precursor cells. Furthermore, two bile acid receptors, FXR and TGR5, were involved in the suppressive effect of CDCA. Taken together, this study suggested that bile acid plays an important role in the proliferation of osteoclast precursor cells.
Keywords
CDCA; osteoclast precursor cells; proliferation;
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