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Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum  

Joo, Si Mong (College of Pharmacy, Sookmyung Women's University)
Hong, Yun Jung (College of Pharmacy, Sookmyung Women's University)
Yang, Ki Sook (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.58, no.1, 2014 , pp. 12-15 More about this Journal
Abstract
Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea, favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and antiinflammatory activity by measuring DPPH radical scavenging activity and the inhibition of IFN-${\gamma}$ and LPS-induced NO production in RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-${\beta}$-Dglucopyranoside (2). Compounds 1 and 2 showed potent activities compared with L-NMMA ($N^G$-monomethyl-L-arginine). These results suggested that the stilbene compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.
Keywords
Polygonum cuspidatum; resveratrol; trans-resveratrol 3-O-${\beta}$-D-glucopyranoside; antiinflammatory agents;
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