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Cognitive Enhancing Activity of the Steamed and Fermented Extracts of Codonopsis lanceolata Radix  

Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Yun, Bo-Ra (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Lee, Hyeon Yong (Department of Teaics, Seowon University)
Park, Dong-Sik (Functional Food & Nutrition Division, Department of Agrofood Resources)
Chung, Hee-Chul (Newtree CO., LTD.)
Chung, Jae Youn (Newtree CO., LTD.)
Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
Publication Information
YAKHAK HOEJI / v.57, no.5, 2013 , pp. 323-329 More about this Journal
Abstract
This study was designed to determine and compare the cognitive enhancing effect of various Codonopsis lanceolata extracts by steaming, fermentation and high hydrostatic pressure process. We prepared water extract of C. lanceolata, steamed C. lanceolata, steamed and fermented C. lanceolata and C.lanceolata by high hydrostatic pressure process and fermentation. Cognitive enhancing effect of extracts was evaluated in scopolamine-induced memory impairment mice using by passive avoidance test and Morris water maze tests. MTT assay was conducted to investigate neuroprotective effect on glutamate induced cell death in HT22 cells. Steamed and fermented C. lanceolata water extract decreased escape latency in Morris water maze test and increased the latency time of the passive avoidance test compared to other extracts. Furthermore, the steamed and fermented C. lanceolata water extract showed neuroprotective effect. These results suggest that steaming and fermentation process more improve cognitive enhancing effect of C. lanceolata than other process.
Keywords
Codonopsis lanceolata; steaming; ferementation; high hydrostatic pressure; cognitive enhancing effect; neuroprotective effect;
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