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Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells  

Jeong, Hwa Hyun (College of Pharmacy, Sookmyung Women's University)
Yoon, Soo Jeong (College of Pharmacy, Sookmyung Women's University)
Pyo, Myoung Yun (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.57, no.5, 2013 , pp. 309-315 More about this Journal
Abstract
Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigated the effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and also decreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulated the protein level of c-Jun, NF-ATc1 and NF-${\kappa}B$ but not c-Fos. Taken together, we suggest that C3G may have suppressive effects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergy symptoms.
Keywords
cyanidin-3-glucoside; IL-4; IL-13; RBL-2H3 cells; antiallergy;
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