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Effect of Lignan Components from Schizandra chinensis on Beta-amyloid Aggregation Inhibition and Dissociation  

Yu, Ho Jin (Institute of Basic Science and Department of Cosmetic Science, College of Natural Sciences, Hoseo University)
Yoon, Mi So (Institute of Basic Science and Department of Cosmetic Science, College of Natural Sciences, Hoseo University)
Kim, Do Yoon (Institute of Basic Science and Department of Cosmetic Science, College of Natural Sciences, Hoseo University)
Won, Kyung-Jong (Departments of Physiology, School of Medicine, Konkuk University)
Kim, Bokyung (Departments of Physiology, School of Medicine, Konkuk University)
Jang, Sang-Hee (Departments of Wellbeing Food, Gumi University)
Lee, Hwan Myung (Institute of Basic Science and Department of Cosmetic Science, College of Natural Sciences, Hoseo University)
Publication Information
YAKHAK HOEJI / v.56, no.5, 2012 , pp. 293-298 More about this Journal
Abstract
The present study tested the effect of Schizandra chinensis lignan compounds, Gomisin A and Schizandrin, on the aggregation and dissociation of beta-amyloid $(A{\beta})_{1-42}$ to explore a possible therapeutic target for Alzheimer's disease. Gomisin A significantly inhibited the $A{\beta}_{1-42}$ aggregation in a dose dependent manner, but did not induced the dissociation of aggregated $A{\beta}_{1-42}$. On the other hand, Schizandrin significantly suppressed the aggregation and dissociation of $A{\beta}_{1-42}$. These results suggest that Gomisin A and Schizandrin, which are known as biologically active ingredients from Schizandra chinensis, may be potentially useful target molecules to develop a drug for the prevention or treatment of Alzheimer's disease.
Keywords
Schizandra chinensis; Alzheimer's disease; beta-amyloid; Schizandrin; Gomisin;
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