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Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent  

Kang, Jin-Ah (College of Pharmacy, Laboratory of Medicinal Chemistry, Pusan National University)
Chun, Pu-Soon (College of Pharmacy, Inje University)
Moon, Hyung-Ryong (College of Pharmacy, Laboratory of Medicinal Chemistry, Pusan National University)
Publication Information
YAKHAK HOEJI / v.56, no.4, 2012 , pp. 230-235 More about this Journal
Abstract
Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives 2~8 with ${\alpha}$-configuration was successfully accomplished using an epoxide-ring opening reaction, lactonization, a hydroboration-oxidation reaction and a Mitsunobu reaction as the key steps. Antiviral activities against HSV-1 and -2, HIV-1 and -2, coxsackie B1and B3 viruses and poliovirus were assayed. Three compounds 4, 7 and 8 exhibit cytotoxicity-derived antiviral activity only in HIV-1 and -2.
Keywords
HSV; nucleosides; Mitsunobu reaction; virus; ${\alpha}$-configuration;
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