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Microemulsion Fomulation for Enhanced Topical Absorption of Root Extract of Angelica gigas  

Jung, Eun-Jae (College of Pharmacy, Seoul National University)
Choi, Joon-Ho (College of Pharmacy, Seoul National University)
Park, Chun-Geon (Deparmtment of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA)
Choi, Ae-Jin (Deparmtment of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA)
Jeong, Se-Ho (College of Pharmacy, Seoul National University)
Chung, Suk-Jae (College of Pharmacy, Seoul National University)
Shim, Chang-Koo (College of Pharmacy, Seoul National University)
Kim, Dae-Duk (College of Pharmacy, Seoul National University)
Publication Information
YAKHAK HOEJI / v.56, no.3, 2012 , pp. 152-157 More about this Journal
Abstract
Angelica gigas is one of the most widely used herbal medicines in Asia. Root extract of Angelica gigas is known to have anti-oxidant activity and skin whitening effect. The aim of this study was to prepare microemulsion system of root extracts of Angelica gigas for topical delivery. Microemulsion was successfully prepared by using MCT (medium chain triglyceride) as an oil phase, Labrasol as a surfactant, and the mixture of propyleneglycol and phosphatidylcholine (4 : 1) as a cosurfactant. In vitro and in vivo skin permeation and deposition of decursin, as a marker, was determined using hairless mouse. Microemulsion significantly increased the in vitro skin permeation of decursin for up to 12 hours and was significantly higher than the control (water). Moreover, microemulsion formulation showed significantly higher skin deposition of decursin compared to the control in both in vitro and in vivo studies. Thus, microemulsion could be a useful vehicle for topical application of root extracts of Angelica gigas.
Keywords
Angelica gigas; Decursin; Topical delivery; Microemulsion;
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