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Development of an Efficient Synthetic Method for a Novel Anticancer Substance Isolated from Insect-flower  

Che, Hai-Yan (College of Pharmacy of Kangwon National University)
Truong, Ngoc Tuyen (College of Pharmacy of Kangwon National University)
Yoon, Deok-Hyo (College of Natural Sciences of Kangwon National University)
Kim, Tae-Woong (College of Natural Sciences of Kangwon National University)
Sung, Gi-Ho (Rural Development Administration)
Park, Hae-Il (College of Pharmacy of Kangwon National University)
Publication Information
YAKHAK HOEJI / v.56, no.2, 2012 , pp. 71-73 More about this Journal
Abstract
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.
Keywords
Cordyceps militaris; militarin; anticancer activity; multi-gram scale;
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