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Effects of Berberine on L-DOPA Therapy in 6-Hydroxydopamine-induced Rat Models of Parkinsonism  

Shin, Kun-Seong (College of Pharmacy, Chungbuk National University)
Kwon, Ik-Hyun (College of Pharmacy, Chungbuk National University)
Choi, Hyun-Sook (College of Pharmacy, Chungbuk National University)
Lim, Sung-Cil (College of Pharmacy, Chungbuk National University)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Lee, Myung-Koo (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.55, no.6, 2011 , pp. 510-515 More about this Journal
Abstract
Isoquinoline compounds including berberine enhance L-DOPA-induced cytotoxicity in PC12 cells. In this study, the effects of berberine on L-DOPA therapy in unilateral 6-hydroxydopamine (6-OHDA)-induced rat models of parkinsonism were investigated. Rats were prepared for the models of Parkinson's disease by 6-OHDA-lesioning for 14 days and then treated with L-DOPA (10 mg/kg) with or without berberine (5 and 30 mg/kg, i.p.) for 21 days. Treatment with berberine (5 and 30 mg/kg, i.p.) showed a dopaminergic cell loss in substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA: 30 mg/kg berberine was more intensive neurotoxic. The levels of dopamine were also decreased by berberine (5 and 30 mg/ kg) in striatum-substantia nigra of 6-OHDA-lesioned rats treated with L-DOPA. These results suggest that berberine aggravates cell death of dopaminergic neurons in L-DOPA-treated 6-OHDA-lesioned rat models of Parkinson's disease. Therefore, the long-term L-DOPA therapeutic patients with isoquinoline compounds including berberine may need to be checked for the adverse symptoms.
Keywords
berberine; dopamine; tyrosine hydroxylase; 6-hydroxydopamine-lesioned rats; Parkinson's disease;
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