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Analysis of Bioconversion Compositions from Fermented Bojungikki-tangs  

Kim, Dong-Seon (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine)
Roh, Joo-Hwan (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine)
Cho, Chang-Won (Regional Food Industry Research Group, Korea Food Research Institute)
Ma, Jin-Yeul (Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine)
Publication Information
YAKHAK HOEJI / v.55, no.5, 2011 , pp. 361-366 More about this Journal
Abstract
Traditional herbal medicinal preparation Bojungikki-tang (BJT) is well-known herbal medicine used as tonic. We fermented Bojungikki-tang using nine lactic acid bacteria strains and discovered two remarkably increased compositions from the fermented BJTs using HPLC/DAD analysis. HPLC/DAD-guided fractionation of the increased compositions followed by structure identification using NMR and MS identified liquiritigenin and isoliquiritigenin. These bioconversion compositions were quantitatively analyzed using HPLC-DAD. Liquiritigenin contents were highest in BJTs fermented with L. amylophilus (1.91 mg/g) and L. fermentum (1.89 mg/g), which were increased by 20-fold compared to BJT (0.09 mg/g). Isoliquiritigenin contents were highest in BJTs in fermented with L. plantarum (0.19 mg/g) and L. fermentum (0.19 mg/g), which were increased by 19-fold compared to BJT (0.01 mg/g).
Keywords
Bojungikki-tang; fermentation; herbal medicine; bioconversion; liquiritigenin; isoliquiritigenin;
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Times Cited By KSCI : 5  (Citation Analysis)
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