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Neuroprotective Effect of the Aerial Parts of Taraxacum officinale on Glutamate-induced Oxidative Injury in Mouse Hippocampal HT22 Cells  

Li, Bin (College of Pharmacy, Wonkwang University)
Lee, Dong-Sung (College of Pharmacy, Wonkwang University)
Choi, Hyun-Gyu (College of Pharmacy, Wonkwang University)
Kim, Kyung-Su (College of Pharmacy, Wonkwang University)
Ji, Hye-Young (College of Pharmacy, Wonkwang University)
Rho, Jung-Mi (College of Pharmacy, Wonkwang University)
Kim, Ki-Mo (College of Pharmacy, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Publication Information
YAKHAK HOEJI / v.55, no.4, 2011 , pp. 314-318 More about this Journal
Abstract
Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. In the present study, we investigated the neuroprotective effects of the standard extracts of Taraxacum officinale Weber, one of the original plants of Taraxaci Herba, on glutamate-induced oxidative injury in mouse hippocampal HT22 cells. The standard EtOH extract of the aerial parts of T. officinale (NNMBS270) showed significant cytoprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells, while the roots' extract (NNMBS271) did not show neuroprotective effect. These results suggest that the extract of the aerial parts of T. officinale could be an effective candidate for the treatment of ROS-related neurological diseases.
Keywords
glutamate-induced toxicity; Taraxaci Herba; Taraxacum officinale; HT22; heme oxygenase-1; neuroprotective effect;
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1 Lee, B. S., Heo, J. H., Kim, Y. M., Shim, S. M., Pae, H. O., Kim, Y. M. and Chung, H. T. : Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells. Biochem. Biophys. Res. Commun. 343, 965 (2006).   DOI   ScienceOn
2 Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J. and Motterlini, R. : Curcumin activates the heme oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371, 887 (2003).   DOI   ScienceOn
3 Rossler, O. G., Bauer, I., Chung, H. Y. and Thiel, G. : Glutamate-induced cell death of immortalized murine hippocampal neurons: neuroprotective activity of heme oxygenase-1, heat shock protein 70, and sodium selenite. Neurosci. Lett. 362, 253 (2004).   DOI   ScienceOn
4 Greenamyre, J. T., Penney, J. B., Young, A. B., D'Amato, C. J. and Hicks, S. P. : Alterations in L-glutamate binding in Alzheimer's and Huntington's disease. Science 4693, 1496 (1985).
5 Choi, D. W. : Glutamate neurotoxicity and disease of the nervous system. Neuron. 1, 623 (1988).   DOI   ScienceOn
6 Lipton, S. A. : Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803 (2007).
7 Satoh, T., Enokido, Y., Kubo, K., Yamada, M. and Hatanaka, H. : Oxygen toxicity induces apoptosis in neuronal cells. Cell Mol. Neurobiol. 18, 649 (1999).
8 Ahmad, V. U., Yasmeen, S., Ali, Z., Khan, M. A., Choudhary, M. I., Akhtar, F., Miana, G. A. and Zahid, M. : Taraxacin, a new guaianolide from Tarazacum wallichii. J. Nat. Prod. 63, 1010 (2000).   DOI   ScienceOn
9 Lee, E. B., Kim, J. K. and Kim, O. K. : The antigastritic effect of Taraxaci Herba. Kor. J. Pharmacogn. 24, 313 (1993).
10 Kang, M. J. and Kim, K. S. : Current trends of research and biological activities of dandelion. Food Ind. Nutr. 6, 60 (2001).
11 Alibright, T. D., Jessel, T. M., Kandel, E. R. and Poster, M. I. : Neural science: a century of progress and the mysteries that remain. Cell 18, 209 (2000).
12 Lee, M. S., Lee, J., Kwon, D. Y. and Kim, M. S. : Ondamtanggamibang protects neurons from oxidative stress with induction of heme oxygenase-1. J. Ethnopharmacol. 108, 294 (2006).   DOI   ScienceOn
13 Morse, D. and Choi, A. M. : Heme oxygenase-1: the "emerging molecule" has arrived. Am. J. Respir. Cell Mol. Biol. 27, 8 (2002).   DOI   ScienceOn
14 Siesjo, B. K. : Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metab. 1, 155 (1981).   DOI
15 Satoh, T., Okamoto, S., Cui, J., Watanabe, Y., Furuta, K., Suzuki, M., Tohyama, K. and Lipton, S. A. : Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc. Natl. Acad. Sci. USA 103, 768 (2006).   DOI   ScienceOn
16 Satoh, T. and Lipton, S. A. : Redox regulation of neuronal survival mediated by electrophilic compounds. Trends Neurosci. 30, 37 (2007).   DOI   ScienceOn
17 Takasaki, M., Konoshima, T., Tokuda, H., Arai, Y., Shiojima, K. and Ageta, H. : Anti-carcinogenic activity of Taraxacum plant. Biol. Pharm. Bull. 22, 602 (1999).   DOI   ScienceOn
18 Kim, T. J. : Korean resources plants. Seoul National University Pub. Co., Seoul, (1996).
19 Cheong, H., Choi, E. J., Yoo, G. S., Kim, K. M. and Ryu, S. Y. : Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum. Planta Med. 64, 577 (1998).   DOI
20 Kisiel, W. and Barszez, B. : Further sesquiterpenoids and phenolics from Taraxacum officinale. Fitoterapia 71, 269 (2000).   DOI   ScienceOn
21 Coyle, J. T. and Puttfarcken, P. : Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689 (1993).   DOI
22 Jeong, G. S., An, R. B., Pae, H. O., Chung, H. T., Yoon, K. H., Kang, D. G., Lee, H. S. and Kim, Y. C. : Cudratricusxanthone A protects mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1. Planta Med. 74, 1368 (2008).   DOI   ScienceOn
23 Bae, K. H. : The medicinal plants of Korea. Kyohak Pub. Co.,Seoul (2000).