Browse > Article

Synthetic Studies Directed Toward an ortho-Fluorination of Phenols  

Jang, Jae-Yong (College of Pharmacy and Medical Research Center, Chungbuk National University)
Kwak, Jae-Hwan (College of Pharmacy and Medical Research Center, Chungbuk National University)
Lee, Hee-Soon (College of Pharmacy and Medical Research Center, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy and Medical Research Center, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.55, no.3, 2011 , pp. 273-276 More about this Journal
Abstract
Synthetic studies directed toward an ortho-fluorination of phenols are described. With eugenol as the test compound, effects of base, fluorination agents, and solvents on ortho-fluorination has been investigated.
Keywords
ortho-fluorination; phenol; methylhonokiol; metabolism;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Hayashi, H., Sonoda, H., Fukumura, K. and Nagata, T. : 2,2- Difluoro-1,3-dimethylimidazolidine (DFI). A new fluorinating agent. Chem. Comm. 1618 (2002).
2 Lal, G. S., Pez, G. P., Pesaresi, R. J., Prozonic, F. M. and Cheng, H. : Bis (2-methoxyethyl) aminosulfur trifluoride: a new broadspectrum deoxofluorinating agent with enhanced thermal stability. J. Org. Chem. 64, 7048 (1999).   DOI   ScienceOn
3 Kirsch, P. : Modern fluoroorganic chemistry, Wiley-VCH, Weinheim, Germany (2004).
4 Lee, Y.-J., Lee, Y. M., Lee, C. K., Jung, J.-K., Han, S. B. and Hong, J. T. : Therapeutic applications of compounds in the Magnolia family. Pharmacol. Ther. 130, 157 (2011).   DOI   ScienceOn
5 Lee, Y. K., Choi, I. S., Ban, J. O., Lee, H. J., Lee, U. S., Han, S. B., Jung, J.-K., Lim, Y. H., Kim, K. H., Oh, K.-W. and Hong, J. T. : 4-O-methylhonokiol attenuated $\beta$-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase. J. Nut. Biochem. 22, 476 (2011).   DOI   ScienceOn
6 Lee, K. and Jung, J.-K. : Unpublished results.
7 Kwak, J.-H., In, J.-K., Lee, M.-S., Choi, E.-H., Lee, H., Hong, J. T., Yun, Y. P., Lee, S. J., Seo, S. Y., Suh, Y.-G. and Jung, J.-K. : Concise synthesis of Obovatol: Chemoselective orthobromination of phenol and survey of Cu-catalyzed diaryl ether couplings. Arch. Pharm. Res. 31, 1559 (2008).   DOI
8 Kirk, K. L. : Fluorine in medicinal chemistry: recent therapeutic applications of fluorinated small molecules. J. Fluorine Chem. 127, 1013 (2006).   DOI   ScienceOn
9 Begue, J. P. and Bonnet-Delpon, D. : Recent advances (1995- 2005) in fluorinated pharmaceuticals based on natural products. J. Fluorine Chem. 127, 992 (2006).   DOI   ScienceOn
10 Isanbor, C. and O'Hagan, D. : Fluorine in medicinal chemistry: a review of anti-cancer agents. J. Fluorine Chem. 127, 303 (2006).   DOI   ScienceOn
11 Roth, B. D. : The discovery and development of atrovastatin, a potent novel hypolipidemic agent. Prog. Med. Chem. 40, 1 (2002).
12 Drlica, K. and Malik, M. : Fluoroquinolones: action and resistance. Curr. Top. Med. Chem. 3(3), 249 (2003).   DOI   ScienceOn
13 Middleton, W. J. : New fluorinating reagents. Dialkylaminosulfur fluorides. J. Org. Chem. 40, 574 (1975).   DOI