Browse > Article

The Sedative Effects of Ethanol Extract from Cimicifugae Rhizoma  

Choi, Yun-Jung (Uimyung Research Institute for Neuroscience, Sahmyook University)
Yoon, Seo-Young (Uimyung Research Institute for Neuroscience, Sahmyook University)
Choi, Ji-Young (Uimyung Research Institute for Neuroscience, Sahmyook University)
Woo, Tae-Seon (Uimyung Research Institute for Neuroscience, Sahmyook University)
Son, Kun-Ho (Department of Food Science and Nutrition, Andong National University)
Lee, Yong-Soo (Department of Pharmacology, College of Pharmacy, Duksung Women's University)
Cheong, Jae-Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
Publication Information
YAKHAK HOEJI / v.55, no.3, 2011 , pp. 213-218 More about this Journal
Abstract
The aim of this study is to evaluate the sedative effects of ethanol extract and the three major constituents of Cimicifugae Rhizoma. They decreased locomotor activity significantly, and enhanced sleeping duration induced by thiopental sodium. The ethanol extract of Cimicifugae rhizoma and 24-epi-7,8-didehydrocimigenol-3-xyloside (24-epi.) increased the $Cl^-$ influx into the intracellular area of SH-SY5Y neuroblastoma cells significantly. The present results demonstrate that the sedative effects of Cimicifugae rhizoma are mediated via the GABA-gated $Cl^-$ channel, partly by 24-epi.
Keywords
Cimicifugae Rhizoma; sedative effect; $Cl^-$ influx; GABA receptor; triterpenoids;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kim, M. K., Yu, G. Y., Tan-Lee, B. S., Oh, H. J., Dong, K. W., Jeong, S. H., Han, S. W. and Cheong, J. H. : Anti-stress effect of Pyroligneous liquid in SD rats and ICR mice. J. Appl. Pharmacol. 11, 249 (2003).
2 Noldus, L. P. J. J., Spink, A. J. and Tegelenbosch, A. J. : EthoVision: A versatile video tracking system for automation of behavioral experiments. Behav. Res. Methods Instrum. Comput. 33, 398 (2001).   DOI   ScienceOn
3 고석태, 임동윤, 강경원 : 새로운 항암성 백금착제의 일반 약리작 용(II). 약학연구지 18, 57 (1996).
4 Verkman, A. S., Sellers, M. C., Chao, A. C., Leung, T. and Ketcham, R. : Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications. Anal. Biochem. 178, 355 (1989).   DOI   ScienceOn
5 West, M. R. and Molloy, C. R. : A microplate assay measuring chloride ion channel activity. Anal. Biochem. 241, 51 (1996).   DOI   ScienceOn
6 Shumaker, H., Amlal, H., Frizzell, R., Ulrich, C. D. Jr. and Soleimani, M. : CFTR drives $Na^+-nHCO3^-$ cotransport in pancreatic duct cells: a basis for defective $HCO3^-$secretion in CF. Am. J. Physiol. 276, C16 (1999).   DOI
7 Cao, L., Sun, H., Li, Z. and Pan, R. L. : Comparison of activities of various species of Rhizoma Cimicifugae and their honey processed products. Zhong Yao Cai. 30, 1561 (2007).
8 양창국 : 불면증의 약물치료. 생물치료정신의학 4, 103 (1998).
9 김인, 최윤경, 서광윤 : 서울 거주 일반인의 수면위생에 대한 인식과 실행. 신경정신의학 36, 712 (1997).
10 Ebert, B., Wafford, K. A. and Deacon, S. :Treating insomnia: Current and investigational pharmacological approaches. Pharmacology & Therapeutics 112, 612 (2006).   DOI   ScienceOn
11 Hirabayashi, T., Ochiai, H., Sakai, S., Nakajima, K. and Terasawa, K. : Inhibitory effect of ferulic acid and isoferulic acid on murine interleukin-8 production in response to influenza virus infections in vitro and in vivo. Planta Med. 61, 221 (1995).   DOI   ScienceOn
12 이현우, 박종욱 : 한국산 승마속 식물(미나리아재비과)의 핵형 분석. 한국식물분류학회 28, 385 (1998).
13 조향순 : 촛대 승마와 황새 승마 뿌리의 항산화 활성 및 Nitric Oxide 생성 억제 활성. 중앙대학교 의약품식품대학원 석사학위논문집 (2007).
14 생약학교재편찬위원회, 생약학, 동명사, 경기도 (2008).
15 Ito, M., Kondo, Y. and Takemoto, T. : Spasmolytic substances from Cimicifuga dahurica maxim. Chem. Pharm. Bull. 24, 580 (1976).   DOI   ScienceOn