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Structure Activity Relationship of Methylchroman-2-carboxylic Acid N-(Disubstituted)phenylamide Derivatives as Potential NF-${\kappa}B$ Inhibitors  

Kim, Tae-Jeong (College of Pharmacy, Chungbuk National University)
Kwak, Jae-Hwan (College of Pharmacy, Chungbuk National University)
Kim, Young-Soo (College of Pharmacy, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University)
Lee, Hee-Soon (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.55, no.2, 2011 , pp. 154-159 More about this Journal
Abstract
During the search for a novel compound that can inhibit NF-${\kappa}B$ activation, 6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide (KL-1156) was identified as a good inhibitor of NF-${\kappa}B$ activation. In the present study, we describe the synthesis of methylchroman-2-carboxylic acid N-(disubstituted)phenylamide derivatives (1 and 2 serieses). In addition, their inhibitory effects of NF-${\kappa}B$ are compared with activity of KL-1156 and SAR (structure activity relationship) are explored.
Keywords
NF-${\kappa}B$; KL-1156; methylchroman; SAR;
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Times Cited By KSCI : 1  (Citation Analysis)
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