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New Organoselenium Compounds; Synthesis of Potential Anticancer Alkylselenoallylthiopyridazine Derivatives  

Lee, Sun-Hee (College of Pharmacy, Duksung Women's University)
Park, Myung-Sook (College of Pharmacy, Duksung Women's University)
Publication Information
YAKHAK HOEJI / v.55, no.1, 2011 , pp. 32-38 More about this Journal
Abstract
A series of new alkylselenoallylthiopyridazine 12~18 was synthesized as expected to retain anticancer activity. Synthetic route for the final compounds 12~18 was proceeded with diselenylation, hydrolysis/alkylation and allylthiolation from 3,6-dichloropyridazine 1. Dichloropyridazinyl diselenide 2 was prepared from the diselenide anion using synthetic route of Bhasin. Diselenide 2 can be reduced to 3-chloropyridazinyl selenolate anion using hydrazine hydrate at rt in the presence of NaOH in THF. The anion thus formed reacts readily with alkyl halide to give the 3-alkylseleno-6-chloropyridazine 3~11. 3-Alkylseleno-6-allylthiopyridazines 12~18 were prepared from 3~11 with allylmercaptan and sodium methoxide.
Keywords
organoselenium; selenopyridazine; alkylselenylation; allylthiopyridazine; anticancer activity;
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Times Cited By KSCI : 4  (Citation Analysis)
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