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Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum  

Joo, Si-Mong (College of Pharmacy, Sookmyung Women's University)
Yang, Ki-Sook (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.54, no.5, 2010 , pp. 387-391 More about this Journal
Abstract
Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O-${\beta}$-D-glucopyranoside (2), emodin 1-O-${\beta}$-D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.
Keywords
Polygonum cuspidatum; emodin; emodin 8-O-${\beta}$-D-glucopyranoside; emodin 1-O-${\beta}$-D-glucopyranoside; antiinflammatory agents;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Wang, C., Zhang D., Ma, H. and Liu, J. : Neuroprotective effects of emodin-8-O-$\beta$-D-glucoside in vivo and in vitro. Eur. J. Pharmacol. 22, 58 (2007).
2 Omur, D., Ayse, K. U., Isabelle, B., H. and Axel, Z. : The structures of antioxidant and cytotoxic agents from natural source: anthraquinones and tannins from roots of Rumex patientia. Phytochemistry 58, 1213 (2001).   DOI   ScienceOn
3 Rui, S., Hui, L., Zunjian, Z., Zhe, L., Lei, X., Haijuan, D. and Yuan, T. : Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition, Rapid Commun. Mass Spec. 23, 537 (2009).   DOI   ScienceOn
4 Jain, R., Mukherjee, K. and Mohan, D. : Effects of nitric oxide synthase inhibitors in attenuating nicotine withdrawal in rats. Pharmacol. Biochem. Behavior. 88, 473 (2008).   DOI   ScienceOn
5 Yann, L. L., Tsong, L. H., Jiuan, W. H. and Jia, Y. F. : Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal uses. Phytother. Resear. 22, 552 (2008).   DOI   ScienceOn
6 Francis, G. W., Aksnes, D. W. and Holt, O. : Assignment of the $^{1}H$ and $^{13}C$ NMR spectra of anthraquinone glycoside from Rhamnus frangula. Magn. Reson. Chem. 36, 769 (1998).   DOI   ScienceOn
7 Hatano, T., Edamatsu, R., Hiramatus, M., Mori, A., Fujita, Y., Yasuhara, T., Yoshita, T. and Okuda, T. : Effects of the interation of tannins with co-existing substances. IV. Efects of tannins and related polyphenols on superoxide anion radical and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37, 2016 (1989).   DOI
8 Wang, S., Zheng, Z., Weng, Y., Yu, Y., Zhang, D., Fan, D. R. and Hu, Z. : Angiogenesis and anti-angiogenesis activity of Chinese medicinal herb extracts. Life Scien. 74, 2467 (2004).   DOI   ScienceOn
9 김지연, 양기숙 : 호장근의 사염화탄소로 유도된 지질과산화 저해 활성. 약학회지 43, 572 (1999).
10 주시몽, 이민원, 양기숙 : 호장으로부터 분리한 안트라퀴논 및 스틸벤 화합물의 지질과산화 저해활성. 약학회지 51, 140 (2007).   과학기술학회마을
11 Jayatilake, G. S., Jayasuriya, H., Lee, E. S., Koonchanok, N. M., Geahien, R. L., Ashendel, C. L., McLaughlin, J. L. and Chang. C. J : Kinase inhibitors from Polygonum cuspidatum. J. Natur. Produc. 56, 1805 (1993).   DOI   ScienceOn
12 Kumar, A., Dhawan, S. and Aggarwal, B. B. : Emodin (3- methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced $NF-{\kappa}B $ activation, $I{\kappa}B$ degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene. 17, 913 (1998).   DOI   ScienceOn
13 Kong, L. Yang, C. and Qiu, X. : Effects of processing on antioxidation of Rheum palmatum and Polygonum cuspidatum. Zhongguo Zhongyao Zazhi 26, 388 (2001).
14 Meng, J. and Hang, H. : Study on the antioxidative activity and stability of Polygonum cuspidatum extract. Huaxue Shijie 41, 418 (2000).
15 Jayasuria, H., Koonchanok, N. M., Geahlen, R., McLaughlin, J. L. and Chang, C. J. : Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J. Natur. Produc. 55, 696 (1992).   DOI
16 Zhao, R. Z., Liu, S. and Zhou, L. I. : Rapid quantitative HPTLC analysis, on one plate, of emodin, resveratrol, and polydatin in the Chinese herb Polygonum cuspidatum. Chromatographia. 61, 311 (2005).   DOI
17 Park, C. S., Lee, Y. C., Kim, J. D. and Kim, C. H. : Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Vascul. Pharmacol. 40, 279 (2004).   DOI   ScienceOn
18 Kim, Y. S., Kim, H. H., Yoo, M. J. and Shin, D. H. : Bactericidal effects of the extracts of Polygonum cuspidatum on Bacillus cereus. Food Sci. Biotech. 13, 4303 (2004).
19 Agarwal, S. K., Singh, S. S., Verma, S. and Kumar, S. : Antifungal activity of anthraquinone derivatives from Rheum emodi. J. Ethnopharmaco. 72, 43 (2000).   DOI   ScienceOn
20 Matsuda, H., Shimoda, H., Morikawa, T. and Yoshikawa, M. : Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorgan. Medicin. Chem. Lett. 11, 1839 (2001).   DOI   ScienceOn
21 Xiao, K., Xuan, L., Xu, Y. and Bai, D. : Stilbene glycoside sulfates from Polygonum cuspidatum. J. Nat. Prod. 63, 1373 (2000).   DOI   ScienceOn
22 Liu, X., Wu, L., Song, G., Liu., K., Zhang, X and Zhang, Y. : Study on the chemical constituents of Polygonum cuspidatum Sieb. Shenyang Yaoke Daxue Xuebao. 16, 17 (1999).
23 Yang, F., Zhang, T. and Ito, Y. : Large-scale separation of resveratrol, anthraglycoside A and anthraglycoside B from Polygonum cuspidatum Sieb. et Zucc by high-speed countercurrent chromatography. J. Chromatogr. A 919, 443 (2001).   DOI   ScienceOn
24 이창복 : 대한식물도감, 향문사, 서울 p. 303 (1980).