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Effects of Histidine Polymers on Mucin Release from Primary Cultured Airway Epithelial Cells  

Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College)
Yun, In-Dae (College of Medicine, Inje University)
Lee, Jae-Woo (LG Life Science)
Lee, Choong-Jae (Department of Pharmacology, School of Medicine, Chungnam National University)
Publication Information
YAKHAK HOEJI / v.54, no.5, 2010 , pp. 334-340 More about this Journal
Abstract
We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^$^3H$$glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on $^3H$-mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.
Keywords
airway mucin; HTSE cells; poly-L-histidine;
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