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Synthesis of 7-Aryloxy-chroman-2-carboxamides and their Evaluation of NF-${\kappa}B$ Inhibitory Activities  

Choi, Eun-Hwa (College of Pharmacy, Chungbuk National University)
Kwak, Jae-Hwan (College of Pharmacy, Chungbuk National University)
Kim, Young-Soo (College of Pharmacy, Chungbuk National University)
Lee, Hee-Soon (College of Pharmacy, Chungbuk National University)
Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.54, no.3, 2010 , pp. 200-204 More about this Journal
Abstract
Nuclear factor-${\kappa}B$ (NF-${\kappa}B$) plays critical roles in physiological and pathological processes such as immune function, cellular growth, homeostasis, apoptosis, and inflammation. As part of our ongoing efforts to develop novel NF-${\kappa}B$ inhibitory agents, we reported that KL-1156 (6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide) exhibited potent inhibitory activity of NF-${\kappa}B$. For further structure-activity relationship, a series of 7-aryloxy-chroman-2-carboxylamide derivatives were synthesized to explore their inhibitory activities of NF-${\kappa}B$.
Keywords
NF-${\kappa}B$; KL-1156; chroman; diaryl ether;
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Times Cited By KSCI : 4  (Citation Analysis)
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