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Effects of N-Acetyl Cysteine and Silymarin on 1-Bromopropane-induced Hepatotoxicity in Mice  

Lee, Sang-Kyu (College of Pharmacy, Yeungnam University)
Kang, Mi-Jeong (College of Pharmacy, Yeungnam University)
Jeon, Tae-Won (Biotoxtech Co., Ltd.)
Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
Publication Information
YAKHAK HOEJI / v.54, no.2, 2010 , pp. 97-101 More about this Journal
Abstract
Recently, it was found that the formation of reactive metabolites by cytochrome P450s as well as the depletion of glutathione would play important roles in hepatotoxicity induced by 1-bromopropane. In the present study, possible roles of anti-oxidants in 1-bromopropane-induced hepatotoxicity were investigated in male ICR mice. The hepatotoxicity induced by 1-bromopropane was significantly protected by the co-treatment with either N-acetyl cysteine or silymarin. 1-Bromopropane-induced decrease in hepatic glutathione level was significantly protected by the pretreatment with N-acetyl cysteine. Taken together, the present results indicated that the reduction of hepatic glutathione level caused by 1-bromopropane treatment might be associated in 1-bromopropane-induced hepatotoxicity in mice.
Keywords
1-bromopropane; hepatotoxicity; N-acetyl cysteine; silymarin; lipid peroxidation; in vivo;
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