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The Inflammation-modulatory Effects of Ginseng Saponin and Polysaccharide on Activated RAW264.7 Cell-line  

Lee, Do-Ik (Department of Immunology, College of Pharmacy, Chung-Ang University)
Publication Information
YAKHAK HOEJI / v.54, no.2, 2010 , pp. 134-141 More about this Journal
Abstract
It is well known that the numbers and functions of immune-associated cells are increased by saponins and polysaccharides in ginseng. In this study, the mixture of polysaccharide and saponin (MPS) from Panax ginseng is applied to LPS- activated RAW 264.7 cells. The production of NO and the gene expression of IL-6 and TNF-$\alpha$ are decreased in LPSactivated RAW 264.7 cells and the expression of arginase II and PD-1L genes is decreased in LPS-untreated macrophages. Therefore, the mixture of saponin and polysaccharide from Panax ginseng could be used in order to regulate immune responses.
Keywords
saponin; Polysaccharide; mixture; inflammation; immunosuppression;
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