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Activation of Hypoxia Inducible Factor-1 Alpha by Estrogen Receptor Alpha  

Ryu, Kwang-Hee (College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University)
Lee, Young-Joo (College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University)
Publication Information
YAKHAK HOEJI / v.54, no.2, 2010 , pp. 102-105 More about this Journal
Abstract
Our previous results showed that hypoxia inducible factor-1 (HIF-1) activated estrogen receptor (ER) in the absence of ligand. In this study, we have studied the effect ER overexpression on the activation of HIF-1. ER overexpression induced transcription activation of hypoxia response element driven luciferase and vascular endothelial growth factor. As a negative control, the effect of ER on androgen receptor response element was used. Our result indicate that the two ER$\alpha$ and HIF-1 signaling pathways shares part of the activation pathway.
Keywords
hypoxia; ER$\alpha$; HIF-1; VEGF;
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1 Kato, S. : Estrogen receptor-mediated cross-talk with growth factor signaling pathways. Breast Cancer 8, 3 (2001).   DOI   ScienceOn
2 Kazi, A. A. and Koos, R. D. : Estrogen-induced activation of hypoxia-inducible factor-1 alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Endocrinology 148, 2363 (2007).   DOI   ScienceOn
3 Lonard, D. M. and O'Malley, B. W. : Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol. Cell. 27, 691 (2007).   DOI   ScienceOn
4 Bos, R., Zhong, H., Hanrahan, C. F., Mommers, E. C., Semenza, G. L., Pinedo, H. M., Abeloff, M. D., Simons, J. W., van Diest, P. J. and van der Wall, E. : Levels of hypoxiainducible factor-1 alpha during breast carcinogenesis. J. Natl. Cancer Inst. 93, 309 (2001).   DOI   ScienceOn
5 Weatherman, R. V. and Scanlan, T. S. : Unique protein determinants of the subtype-selective ligand responses of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites. J. Biol. Chem. 276, 3827 (2001).   DOI   ScienceOn
6 Kelly, M. J. and Levin, E. R. : Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol Metab. 12, 152 (2001).   DOI   ScienceOn
7 Taylor, C. T. and Colgan, S. P. : Therapeutic targets for hypoxiaelicited pathways. Pharm. Res. 16, 1498 (1999).   DOI   ScienceOn
8 Ohtake, F., Takeyama, K., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., Yanagisawa, J., Fujii-Kuriyama, Y. and Kato, S. : Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423, 545 (2003).   DOI   ScienceOn
9 Shao, W. and Brown, M. : Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res. 6, 39 (2004).   DOI   ScienceOn
10 Stoner, M., Saville, B., Wormke, M., Dean, D., Burghardt, R. and Safe, S. : Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells. Mol. Endocrinol. 16, 2231 (2002).   DOI   ScienceOn
11 Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M. and Gustafsson, J. A. : Mechanisms of estrogen action. Physiol. Rev. 81, 1535 (2001).
12 Gu, Y.-Z., Hogenesch, J. B. and Bradfield, C. A. : The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40, 519 (2000).   DOI   ScienceOn
13 Wang, G. L., Jiang Bing-Hua., Rue, E. A. and Semenza, G. L. : Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular $O_2$ tension. Proc. Natl. Acad. Sci. USA 92, 5510 (1995).   DOI   ScienceOn
14 Brunnberg, S., Pettersson, K., Rydin, E., Matthews, J., Hanberg, A. and Pongratz, I. : The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc. Natl. Acad. Sci. USA 100, 6517 (2003).   DOI   ScienceOn