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Antimicrobial Activity of Resveratrol Oligomers and Flavonoids from the Stems of Vitis coignetiae Pulliat and the Seeds of Perilla frutescens (L.) Britton  

Son, Rak-Ho (R&D Center, Jung San Bio Technology)
Chin, Hwi-Seung (R&D Center, Jung San Bio Technology)
Ham, Ah-Rom (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Nam, Kung-Woo (R&D Center, Jung San Bio Technology)
Publication Information
YAKHAK HOEJI / v.54, no.1, 2010 , pp. 22-26 More about this Journal
Abstract
We studied the antimicrobial activities of five compounds isolated from the stems of Vitis coignetiae Pulliat and the seeds of Perilla frutescens (L.) Britton. Based on spectroscopic evidence, compounds 1 to 5 were characterized as resveratrol, $\varepsilon$-viniferin, ampelopsin E, apigenin, and luteolin, respectively. The antimicrobial activities against Gram-positive (Staphylococcus aureus) and -negative (Pseudomonas aeruginosa) bacteria and a fungus (Candida albicans) were investigated using the disc diffusion and broth dilution methods. C. albicans was not inhibited by the five compounds. Compounds 2 and 5 had significant anti-microbial activity against S. aureus, and the 50% inhibitory concentration ($IC_{50}$) of compound 2 against S. aureus was 7.2 ${\mu}M$. Compounds 4 and 5 significantly inhibited P. aeruginosa and the minimum inhibitory concentration (MIC) of compounds 2 and 5 was 0.07 and 2.0 ${\mu}M$, respectively. Compounds 2, 4, and 5 had strong anti-microbial activity against S. aureus and P. aeruginosa.
Keywords
Vitis coignetiae; Perilla frutescens; antimicrobial;
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