Browse > Article

Studies on the Antiinflammatory Compounds from Sorbus Commixta  

Yun, Young-Gab (Department of Oriental Medical Prescription, School of Oriental Medicine, Wonkwang University)
Chai, Kyu-Yun (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University)
Lee, Kyung-Kwan (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University)
Bhatt, Lok Ranjan (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University)
Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
YAKHAK HOEJI / v.53, no.6, 2009 , pp. 351-356 More about this Journal
Abstract
Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.
Keywords
Sorbus commixta; sakuranetin; prunetin; dihydroquercetin; anti-inflammatory effects; NO; PEG2;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Galla, H. J. : Nitric oxide, NO, an intercellular messenger Angew. Chem. Int. Ed. Engl. 32, 378 (1993)   DOI   ScienceOn
2 Peng, T., Tu, Y. Q., Deng, Y. and Zhang, X. : Studies on chemical constituents of Primula sikkmensis. Zhong Yao Cai. 31, 44 (2008)
3 de Almeida, J. G., Silveira, E. R. and Pessoa, O. D. : NMR spectral assignments of a new [C--O--C] isoflavone dimer from Andira surinamensis. Magn. Reson. Chem. 46, 103 (2008)   DOI   ScienceOn
4 Wang, Y., Vodovotz, Y., Kim, P. K., Zamora, R. and Billiar, T. R. : Mechanisms of hepatoprotection by nitric oxide. Ann. N. Y. Acad. Sci. 962, 415 (2002)   DOI   PUBMED   ScienceOn
5 Chun, H. T., Pae, H. O., Choi, B. M., Billiar, T. R. and Kim, Y. M. : Nitric oxide as a bioregulator of apoptosis. Biochem. Biophys. Res. Commun. 282, 1075 (2001)   DOI   ScienceOn
6 Tsydendambaev, P. B., Khyshiktyev, B. S., Dutov, A. A., Nikolaev, S. M. and Savin, A. V. : High-performance liquid chromatographic method for the determination of dihydroquercetin in extracts of medicinal plants. Biomed. Khim. 53, 212 (2007)   PUBMED
7 Bae, K. : The Medicinal Plants of Korea, Kyo-Hak Publishing Co., Seoul, Korea, p. 236 (2000)
8 Brieva, A., Guerrero, A., Alonso-Lebrero, J. L. and Pivel, J. P. : Inmunoferon${\circledR}$, a glycoconjugate of natural origin, inhibits LPS-induced TNF-$\alpha$ production and inflammatory responses. Int. Immunopharmacol. 1, 1979 (2001)   DOI   ScienceOn
9 Rakwal, R., Hasegawa, M. and Kodama, O. : A methyltransferase for synthesis of the flavanone phytoalexin sakuranetin in rice leaves. Biochem. Biophys. Res. Comm. 222, 732 (1996)   DOI   ScienceOn
10 Cox, G. W., Melillo, G., Chattopadhyay, G., Mullet, D., Fertel, R. H. and Varesio, L. : Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFNgamma plus IL-2-induced murine macrophage tumoricidal activity J. Immunol. 149, 3290 (1992)
11 Rho, J. R., Jun, C. S., Ha, Y. A., Yoo, M. J., Cui, M. X., Baek, S. H., Lim, J. A., Lee, Y. H. and Chai, K. Y. : Isolation and characterization of a new alkaloid from the seed of Prunus persica L. and its antiinflammatory activity. Bull. Korea Chem. Soc. 28, 1289 (2007)   DOI   ScienceOn
12 Narumi, S., Finke, J. H. and Hamilton, T. A. : Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. J. Biol. Chem. 265, 7036 (1990)   PUBMED
13 Lee, S. M. and Lee, C. G. : Isolation and gas chromatographic analysis of lupenone and lupeol from Sorbus Cortex. Anal. Sci. Technol. 12, 136 (1999)
14 You, M. J., Kim, B. M., Bhatt, L. R., Chai, K. Y. and Baek, S. H. : Inhibitory effect of sakuranetin on (1,3)-$\beta$-glucan synthase. Orien. Pharm. Exp. Med. submitted
15 Kawaguchi, M., Tanabe, H. and Nagamine, K. : Isolation and characterization of a novel flavonoid possessing a 4,2"- glycosidic linkage from green mature acerola (Malpighia emarginata DC.) fruit. Biosci. Biotechnol. Biochem. 71, 1130 (2007)   DOI   ScienceOn