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Combination of Green Tea Extract and L-Theanine Alleviates Electric Foot Shock Induced Stress by Modulating Neurotransmitters in Mice  

Park, Sang-Ki (LG Household and Healthcare Research Park)
Kim, Tae-Il (LG Household and Healthcare Research Park)
Lee, Won-Kyung (LG Household and Healthcare Research Park)
Park, Hyoung-Kook (LG Household and Healthcare Research Park)
Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
Publication Information
YAKHAK HOEJI / v.53, no.5, 2009 , pp. 241-249 More about this Journal
Abstract
Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the combination relieving effect of green tea extract(GTE) and L-theanine on the stress induced by electric foot shock. Four week oral administration of GTE (24 mg/kg), L-theanine (4 mg/kg) or their combination reduced the levels of dopamine, noradrenaline and corticosterone in blood, brain cortex, hippocampus, and striatum, wherease increased serotonin level. The combination of GTE and L-theanine showed much greater effects than single treatment of each component, and the effects are comparable to diazepam (2 mg/kg). Therefore, this study suggests that the combination of GTE and L-theanine may act effective and be useful for stress relieving treatment.
Keywords
green tea extract; L-theanine; anti-stress; neurotransmitter;
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