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Lignans Isolated from the Roots of Patrinia scabiosaefolia F. and their IL(Interleukin)-6 Inhibitory Activity  

Choi, Eun-Jin (College of Pharmacy, Chosun University)
Jin, Qinglong (College of Pharmacy, Chosun University)
Shin, Ji-Eun (College of Pharmacy, Chosun University)
Kim, Hyun-Gyu (HL Genomics Co.)
Kim, Jung-Jin (HL Genomics Co.)
Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Publication Information
YAKHAK HOEJI / v.53, no.4, 2009 , pp. 201-205 More about this Journal
Abstract
In an ongoing investigation into anti-inflammatory compounds from natural products, the $CH_2Cl_2$ soluble fraction of Patrinia scabiosaefolia F. (Valerianaceae) was found to inhibit IL-6 production in TNF-$\alpha$ stimulated MG-63 cell line. By means of a bioassay-directed chromatographic separation technique, lappaol E (1), and nortrachelogenin (2) were isolated. These compounds have been isolated from this plant for the first time. Compounds $1{\sim}2$ showed potent antioxidative activity using NBT superoxide scavenging assay. Moreover, compound 1 decreased IL-6 production in TNF-$\alpha$ stimulated MG-63 cell line.
Keywords
lappaol E; nortrachelogenin; IL (interleukin)-6; anti-inflammatory activity; antioxidative; Patrinia scabiosaefolia F.;
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